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@article{Smith:2024:10.1038/s41564-024-01626-9,
author = {Smith, TP and Clegg, T and Ransome, E and Martin-Lilley, T and Rosindell, J and Woodward, G and Pawar, S and Bell, T},
doi = {10.1038/s41564-024-01626-9},
journal = {Nature Microbiology},
pages = {938--948},
title = {High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants},
url = {http://dx.doi.org/10.1038/s41564-024-01626-9},
volume = {9},
year = {2024}
}
TY - JOUR
AB - Our understanding of how microbes respond to micropollutants, such as pesticides, is almost wholly based on single-species responses to individual chemicals. However, in natural environments, microbes experience multiple pollutants simultaneously. Here we perform a matrix of multi-stressor experiments by assaying the growth of model and non-model strains of bacteria in all 255 combinations of 8 chemical stressors (antibiotics, herbicides, fungicides and pesticides). We found that bacterial strains responded in different ways to stressor mixtures, which could not be predicted simply from their phylogenetic relatedness. Increasingly complex chemical mixtures were both more likely to negatively impact bacterial growth in monoculture and more likely to reveal net interactive effects. A mixed co-culture of strains proved more resilient to increasingly complex mixtures and revealed fewer interactions in the growth response. These results show predictability in microbial population responses to chemical stressors and could increase the utility of next-generation eco-toxicological assays.
AU - Smith,TP
AU - Clegg,T
AU - Ransome,E
AU - Martin-Lilley,T
AU - Rosindell,J
AU - Woodward,G
AU - Pawar,S
AU - Bell,T
DO - 10.1038/s41564-024-01626-9
EP - 948
PY - 2024///
SN - 2058-5276
SP - 938
TI - High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants
T2 - Nature Microbiology
UR - http://dx.doi.org/10.1038/s41564-024-01626-9
UR - https://www.ncbi.nlm.nih.gov/pubmed/38499812
UR - http://hdl.handle.net/10044/1/110907
VL - 9
ER -
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