@article{Yuen:2024:10.1016/j.cub.2024.04.002,
author = {Yuen, ELH and Leary, AY and Clavel, M and Tumtas, Y and Mohseni, A and Zhao, J and Picchianti, L and Jamshidiha, M and Pandey, P and Duggan, C and Cota, E and Dagdas, Y and Bozkurt, TO},
doi = {10.1016/j.cub.2024.04.002},
journal = {Curr Biol},
pages = {2049--2065.e6},
title = {A RabGAP negatively regulates plant autophagy and immune trafficking.},
url = {http://dx.doi.org/10.1016/j.cub.2024.04.002},
volume = {34},
year = {2024}
}

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TY  - JOUR
AB  - Plants rely on autophagy and membrane trafficking to tolerate stress, combat infections, and maintain cellular homeostasis. However, the molecular interplay between autophagy and membrane trafficking is poorly understood. Using an AI-assisted approach, we identified Rab3GAP-like (Rab3GAPL) as a key membrane trafficking node that controls plant autophagy negatively. Rab3GAPL suppresses autophagy by binding to ATG8, the core autophagy adaptor, and deactivating Rab8a, a small GTPase essential for autophagosome formation and defense-related secretion. Rab3GAPL reduces autophagic flux in three model plant species, suggesting that its negative regulatory role in autophagy is conserved in land plants. Beyond autophagy regulation, Rab3GAPL modulates focal immunity against the oomycete pathogen Phytophthora infestans by preventing defense-related secretion. Altogether, our results suggest that Rab3GAPL acts as a molecular rheostat to coordinate autophagic flux and defense-related secretion by restraining Rab8a-mediated trafficking. This unprecedented interplay between a RabGAP-Rab pair and ATG8 sheds new light on the intricate membrane transport mechanisms underlying plant autophagy and immunity.
AU  - Yuen,ELH
AU  - Leary,AY
AU  - Clavel,M
AU  - Tumtas,Y
AU  - Mohseni,A
AU  - Zhao,J
AU  - Picchianti,L
AU  - Jamshidiha,M
AU  - Pandey,P
AU  - Duggan,C
AU  - Cota,E
AU  - Dagdas,Y
AU  - Bozkurt,TO
DO  - 10.1016/j.cub.2024.04.002
EP  - 2065
PY  - 2024///
SP  - 2049
TI  - A RabGAP negatively regulates plant autophagy and immune trafficking.
T2  - Curr Biol
UR  - http://dx.doi.org/10.1016/j.cub.2024.04.002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38677281
VL  - 34
ER  - 

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