@article{Rebuffet:2024:10.1038/s41590-024-01883-0,
author = {Rebuffet, L and Melsen, JE and Escalière, B and Basurto-Lozada, D and Bhandoola, A and Björkström, NK and Bryceson, YT and Castriconi, R and Cichocki, F and Colonna, M and Davis, DM and Diefenbach, A and Ding, Y and Haniffa, M and Horowitz, A and Lanier, LL and Malmberg, K-J and Miller, JS and Moretta, L and Narni-Mancinelli, E and O'Neill, LAJ and Romagnani, C and Ryan, DG and Sivori, S and Sun, D and Vagne, C and Vivier, E},
doi = {10.1038/s41590-024-01883-0},
journal = {Nat Immunol},
title = {High-dimensional single-cell analysis of human natural killer cell heterogeneity.},
url = {http://dx.doi.org/10.1038/s41590-024-01883-0},
year = {2024}
}

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TY  - JOUR
AB  - Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to dissect the heterogeneity of NK cells. We identified three prominent NK cell subsets in healthy human blood: NK1, NK2 and NK3, further differentiated into six distinct subgroups. Our findings delineate the molecular characteristics, key transcription factors, biological functions, metabolic traits and cytokine responses of each subgroup. These data also suggest two separate ontogenetic origins for NK cells, leading to divergent transcriptional trajectories. Furthermore, we analyzed the distribution of NK cell subsets in the lung, tonsils and intraepithelial lymphocytes isolated from healthy individuals and in 22 tumor types. This standardized terminology aims at fostering clarity and consistency in future research, thereby improving cross-study comparisons.
AU  - Rebuffet,L
AU  - Melsen,JE
AU  - Escalière,B
AU  - Basurto-Lozada,D
AU  - Bhandoola,A
AU  - Björkström,NK
AU  - Bryceson,YT
AU  - Castriconi,R
AU  - Cichocki,F
AU  - Colonna,M
AU  - Davis,DM
AU  - Diefenbach,A
AU  - Ding,Y
AU  - Haniffa,M
AU  - Horowitz,A
AU  - Lanier,LL
AU  - Malmberg,K-J
AU  - Miller,JS
AU  - Moretta,L
AU  - Narni-Mancinelli,E
AU  - O'Neill,LAJ
AU  - Romagnani,C
AU  - Ryan,DG
AU  - Sivori,S
AU  - Sun,D
AU  - Vagne,C
AU  - Vivier,E
DO  - 10.1038/s41590-024-01883-0
PY  - 2024///
TI  - High-dimensional single-cell analysis of human natural killer cell heterogeneity.
T2  - Nat Immunol
UR  - http://dx.doi.org/10.1038/s41590-024-01883-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38956378
ER  - 

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