In this section
@article{Jaramillo:2024:sleep/zsae193,
author = {Jaramillo, V and Hebron, H and Wong, S and Atzori, G and Bartsch, U and Dijk, D-J and Violante, IR},
doi = {sleep/zsae193},
journal = {Sleep},
title = {Closed-loop auditory stimulation targeting alpha and theta oscillations during rapid eye movement sleep induces phase-dependent power and frequency changes.},
url = {http://dx.doi.org/10.1093/sleep/zsae193},
volume = {47},
year = {2024}
}
TY - JOUR
AB - STUDY OBJECTIVES: Alpha and theta oscillations characterize the waking human electroencephalogram (EEG) and can be modulated by closed-loop auditory stimulation (CLAS). These oscillations also occur during rapid eye movement (REM) sleep, but their function here remains elusive. CLAS represents a promising tool to pinpoint how these brain oscillations contribute to brain function in humans. Here we investigate whether CLAS can modulate alpha and theta oscillations during REM sleep in a phase-dependent manner. METHODS: We recorded high-density EEG during an extended overnight sleep period in 18 healthy young adults. Auditory stimulation was delivered during both phasic and tonic REM sleep in alternating 6-second ON and 6-second OFF windows. During the ON windows, stimuli were phase-locked to four orthogonal phases of ongoing alpha or theta oscillations detected in a frontal electrode. RESULTS: The phases of ongoing alpha and theta oscillations were targeted with high accuracy during REM sleep. Alpha and theta CLAS induced phase-dependent changes in power and frequency at the target location. Frequency-specific effects were observed for alpha trough (speeding up) and rising (slowing down) and theta trough (speeding up) conditions. CLAS-induced phase-dependent changes were observed during both REM sleep substages, even though auditory evoked potentials were very much reduced in phasic compared to tonic REM sleep. CONCLUSIONS: This study provides evidence that faster REM sleep rhythms can be modulated by CLAS in a phase-dependent manner. This offers a new approach to investigating how modulation of REM sleep oscillations affects the contribution of this vigilance state to brain function.
AU - Jaramillo,V
AU - Hebron,H
AU - Wong,S
AU - Atzori,G
AU - Bartsch,U
AU - Dijk,D-J
AU - Violante,IR
DO - sleep/zsae193
PY - 2024///
TI - Closed-loop auditory stimulation targeting alpha and theta oscillations during rapid eye movement sleep induces phase-dependent power and frequency changes.
T2 - Sleep
UR - http://dx.doi.org/10.1093/sleep/zsae193
UR - https://www.ncbi.nlm.nih.gov/pubmed/39208441
VL - 47
ER -
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