In this section
@article{Gallo:2017:10.1039/c7nr01733b,
author = {Gallo, J and Harriss, BI and Hernandez-Gil, J and Banobre-Lopez, M and Long, NJ},
doi = {10.1039/c7nr01733b},
journal = {Nanoscale},
pages = {11318--11326},
title = {Probing T-1-T-2 interactions and their imaging implications through a thermally responsive nanoprobe},
url = {http://dx.doi.org/10.1039/c7nr01733b},
volume = {9},
year = {2017}
}
TY - JOUR
AB - The complex and specialised diagnostic process through magnetic resonance imaging (MRI) could be simplified with the implementation of dual T1–T2 contrast agents. T1- and T2-weighted MR are compatible modalities, and co-acquisition of contrast enhanced images in both T1 and T2 will drastically reduce artefacts and provide double-checked results. To date, efforts in the development of dual MRI probes have provided inconsistent results. Here we present the preparation and relaxometric study of a dual T1–T2 MRI probe based on superparamagnetic nanoparticles, paramagnetic Gd3+ chelates and pNIPAM (poly(N-isopropylacrylamide)), in which the distance between paramagnetic and superparamagnetic species can be modulated externally via temperature variations. Such a probe alleviates traditional nanotechnology limitations (e.g. batch to batch variability) as comparisons can be established within a single probe.
AU - Gallo,J
AU - Harriss,BI
AU - Hernandez-Gil,J
AU - Banobre-Lopez,M
AU - Long,NJ
DO - 10.1039/c7nr01733b
EP - 11326
PY - 2017///
SN - 2040-3364
SP - 11318
TI - Probing T-1-T-2 interactions and their imaging implications through a thermally responsive nanoprobe
T2 - Nanoscale
UR - http://dx.doi.org/10.1039/c7nr01733b
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407336600038&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/53270
VL - 9
ER -
Professor Nick Long
Email: n.long@imperial.ac.uk
Telephone: +44 (0)20 7594 5781
501J
Molecular Sciences Research Hub
White City Campus
