BibTex format
@article{Li:2017:10.7150/ntno.18619,
author = {Li, H and Harriss, BI and Phinikaridou, A and Lacerda, S and Ramniceanu, G and Doan, B-T and Ho, K-L and Chan, C-F and Lo, W-S and Botnar, RM and Lan, R and Richard, C and Law, G-L and Long, NJ and Wong, K-L},
doi = {10.7150/ntno.18619},
journal = {Nanotheranostics},
pages = {186--195},
title = {Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.},
url = {http://dx.doi.org/10.7150/ntno.18619},
volume = {1},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.
AU - Li,H
AU - Harriss,BI
AU - Phinikaridou,A
AU - Lacerda,S
AU - Ramniceanu,G
AU - Doan,B-T
AU - Ho,K-L
AU - Chan,C-F
AU - Lo,W-S
AU - Botnar,RM
AU - Lan,R
AU - Richard,C
AU - Law,G-L
AU - Long,NJ
AU - Wong,K-L
DO - 10.7150/ntno.18619
EP - 195
PY - 2017///
SN - 2206-7418
SP - 186
TI - Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.
T2 - Nanotheranostics
UR - http://dx.doi.org/10.7150/ntno.18619
UR - http://hdl.handle.net/10044/1/53267
VL - 1
ER -
