BibTex format
@article{Nasser:2016:10.1016/j.ygyno.2016.08.322,
author = {Nasser, S and Lazaridis, A and Evangelou, M and Jones, B and Nixon, K and Kyrgiou, M and Gabra, H and Rockall, A and Fotopoulou, C},
doi = {10.1016/j.ygyno.2016.08.322},
journal = {Gynecologic Oncology},
pages = {264--269},
title = {Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation},
url = {http://dx.doi.org/10.1016/j.ygyno.2016.08.322},
volume = {143},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - ObjectivesComputed tomography (CT) is an essential part of preoperative planning prior to cytoreductive surgery for primary and relapsed epithelial ovarian cancer (EOC). Our aim is to correlate pre-operative CT results with intraoperative surgical and histopathological findings at debulking surgery.MethodsWe performed a systematic comparison of intraoperative tumor dissemination patterns and surgical resections with preoperative CT assessments of infiltrative disease at key resection sites, in women who underwent multivisceral debulking surgery due to EOC between January 2013 and December 2014 at a tertiary referral center. The key sites were defined as follows: diaphragmatic involvement(DI), splenic disease (SI), large (LBI) and small (SBI) bowel involvement, rectal involvement (RI), porta hepatis involvement (PHI), mesenteric disease (MI) and lymph node involvement (LNI).ResultsA total of 155 patients, mostly with FIGO stage IIIC disease (65%) were evaluated (primary = 105, relapsed = 50). Total macroscopic cytoreduction rates were: 89%. Pre-operative CT findings displayed high specificity across all tumor sites apart from the retroperitoneal lymph node status, with a specificity of 65%.The ability however of the CT to accurately identify sites affected by invasive disease was relatively low with the following sensitivities as relating to final histology:32% (DI), 26% (SI), 46% (LBI), 44% (SBI), 39% (RI), 57% (PHI), 31% (MI), 63% (LNI).ConclusionPre-operative CT imaging shows high specificity but low sensitivity in detecting tumor involvement at key sites in ovarian cancer surgery. CT findings alone should not be used for surgical decision making.
AU - Nasser,S
AU - Lazaridis,A
AU - Evangelou,M
AU - Jones,B
AU - Nixon,K
AU - Kyrgiou,M
AU - Gabra,H
AU - Rockall,A
AU - Fotopoulou,C
DO - 10.1016/j.ygyno.2016.08.322
EP - 269
PY - 2016///
SN - 1095-6859
SP - 264
TI - Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation
T2 - Gynecologic Oncology
UR - http://dx.doi.org/10.1016/j.ygyno.2016.08.322
UR - http://hdl.handle.net/10044/1/43413
VL - 143
ER -