@article{Akerman:2017:10.1016/j.cmet.2016.11.016,
author = {Akerman, I and Tu, Z and Beucher, A and Rolando, DM and Sauty-Colace, C and Benazra, M and Nakic, N and Yang, J and Wang, H and Pasquali, L and Moran, I and Garcia-Hurtado, J and Castro, N and Gonzalez-Franco, R and Stewart, AF and Bonner, C and Piemonti, L and Berney, T and Groop, L and Kerr-Conte, J and Pattou, F and Argmann, C and Schadt, E and Ravassard, P and Ferrer, J},
doi = {10.1016/j.cmet.2016.11.016},
journal = {Cell Metabolism},
pages = {400--411},
title = {Human pancreatic β cell incRNAs control cell-specific regulatory networks},
url = {http://dx.doi.org/10.1016/j.cmet.2016.11.016},
volume = {25},
year = {2017}
}

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TY  - JOUR
AB  - Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate β cell-specific transcriptional networks. We further demonstrate that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key β cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of β cell-specific transcription factor networks.
AU  - Akerman,I
AU  - Tu,Z
AU  - Beucher,A
AU  - Rolando,DM
AU  - Sauty-Colace,C
AU  - Benazra,M
AU  - Nakic,N
AU  - Yang,J
AU  - Wang,H
AU  - Pasquali,L
AU  - Moran,I
AU  - Garcia-Hurtado,J
AU  - Castro,N
AU  - Gonzalez-Franco,R
AU  - Stewart,AF
AU  - Bonner,C
AU  - Piemonti,L
AU  - Berney,T
AU  - Groop,L
AU  - Kerr-Conte,J
AU  - Pattou,F
AU  - Argmann,C
AU  - Schadt,E
AU  - Ravassard,P
AU  - Ferrer,J
DO  - 10.1016/j.cmet.2016.11.016
EP  - 411
PY  - 2017///
SN  - 1932-7420
SP  - 400
TI  - Human pancreatic β cell incRNAs control cell-specific regulatory networks
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2016.11.016
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28041957
UR  - https://www.sciencedirect.com/science/article/pii/S1550413116305952?via%3Dihub
UR  - http://hdl.handle.net/10044/1/43718
VL  - 25
ER  - 

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