1. Very common risk: Developing gastroenteritis

How is it minimised?

• Participants are treated with antibiotics to shorten duration.
• Monitored for dehydration and given fluids to rehydrate

2. Uncommon risk: Invasive Salmonella infection

How is it minimised?

• High risk people are excluded from the study.
• Daily blood samples test for bacteria in the blood.
• Immediate treatment to prevent severe symptoms.

3. Common risk: Antibiotic side effects

How is it minimised?

• People with known allergies are excluded.
• Treatment is as short as possible.
• We monitor for and treat any side effects.
• We can use alternative antibiotics if side effects occur.

4. Common risk: Post infectious irritable bowel syndrome (IBS)

How is it minimised?

• Screening questionnaire for symptoms of IBS.
• If symptoms don’t resolve, referral to a specialist.

5. Uncommon risk: Reactive arthritis (joint pain/swelling)

How is it minimised?

• A screening blood test for HLA-B27
• If symptoms occur, referral to a specialist.

6. Uncommon risk: Transmission or shedding

How is it minimised?

• Quarantine until no longer infectious.
• Participants given information and soap/disposable towels for good handwashing.
• Testing at follow up visits.
• Close contacts can be tested for Salmonella.