Regulation of insulin secretion hotspots by the GLP-1 receptor
Optimisation of an ultra fast assay for metabolic profiling: application to clinical studies
Can Non-Invasive Vagus Nerve Stimulation alter the Cholinergic Metabolome in Parkinson’s Disease patients?
The feasibility and accuracy of a markerless motion capture for measuring parameters related to both normal and osteoarthritic gait and daily activities.
Wearable microneedle aptasensor of psychiatric biomarkers in mental health monitoring
Generating a Methyl-Proteomics Library for Studying Protein Methylation in Cancer
Immune-regulatory role of IL-27 axis in liver injury
Development and optimization of proteomic and metabolomic analysis of biological samples using Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry
NNAT aggregation and loss of heterogeneity as causative factors in beta cell dysfunction in diabetes
Towards elucidation of 3D myocardial microstructure by ex-vivo Diffusion Tensor Cardiac Magnetic Resonance and 3D Histology
Developing a chick chorioallantoic membrane (CAM) assay as an xenograft model to study soft-tissue sarcoma drug development
Molecular mechanisms underpinning the extensive, multi-organelle dysfunction caused by the toxin L-amino acid oxidase
The role of mTORC2 in regulation of hESC stiffness and cell fate
Transient PiggyBac-based Genome Engineering to Produce Human Pluripotent Stem Cells
AstraZeneca Sponsored Project: Proteomic analysis of human mesenchymal stem cell cross-talk with haematopoietic stem cells in 3 dimensional niche of complex in vitro model of bone marrow
Anaesthetics, Pain Medicine and Intensive Care
Investigating the importance of microvesicle-delivered FADD on epithelial cell function during ventilator-induced lung injury
Evaluation of a novel medical device to prevent epidural hyperthermia
Evidence Synthesis to Inform Neuropathic Pain Mangement
Modelling labour contraction pain through Electrical muscle stimulation.
The role of the nuclear enzyme mitogen- and stress-activated kinase 1 in noxious heat sensitivity of primary sensory neutrons
Mechanisms of monocyte de-activation by neutrophil extracellular vesicles in sepsis
Modulation of neutrophil extracellular vesicle pro-inflammatory activity by complement
The effects of blocking MSK1 on tissue inflammation and wound healing
Neutrophil extracellular trap production in severe febrile illness in children
Preclinical investigation of brain injury due to carbon monoxide poisoning
Bacterial Pathogenesis and Infection
Analysis of OMV-based vaccine strategies to combat Avian Pathogenic Escherichia coli (APEC)
Exploring the mechanism of Salmonella effector kinase, SteC, in the mammalian host
Investigating the role of TRIM E3 ligase proteins during Salmonella infection
Poisons and antidotes - defining the antibacterial effector repertoire of Pseudomonas aeruginosa’s T6SS
Pathogenicity island transduction and the evolution of bacterial pathogens
Impact of targeting inhibitory immune receptors by urogenital bacterial pathogens.
Using a Fluorescence-activated cell sorting (FACS)-based screen to identify novel factors that regulate c-di-AMP production in Staphylococcus aureus.
Understanding golden staph and its friends: genomic analysis of staphylococcal nasal carriage in UK military personnel at high risk of skin infections
The role of KRT10 in invasive bacterial infections of childhood
Understanding the pathogenesis of the priority nosocomial pathogen Enterobacter cloacae
Data Science
Physics-Informed Neural Networks to Predict Blood Glucose Levels in Patients with Type-I Diabetes
Explainable prognostic models for progressive pulmonary fibrosis
Border Rendering Feature Orthogonal Network for Blood Vessel Segmentation
Revealing the hidden fingerprints of drug exposure and metabolism in population-scale metabolomics data by statistical correlation and database development.
Integrative analysis of single-cell RNA-Seq data to explore the association of mosaic loss of chromosome Y with idiopathic pulmonary fibrosis
Exploring Expression Patterns and Shared Genetic Mechanisms in MS through Integrative Genetic Analysis
Unpaired Style Mapping using Generative Models Techniques for Medical Image Segmentation
Characteristics of Urinary Pathogens in People Living with Dementia
Integrating transcriptomic, epigenomic, and transcription factor binding data to unravel the function of TSPO in microglia.
Machine Learning Applications to Radiomics of Early Pregnancy Ultrasound To Predict Miscarriage
Epidemiology, Evolution and Control of Infectious Diseases
A systematic review and estimation of the effects of temperature on yellow fever vector development and survival
Estimating the impact of cholera interventions on disease burden in Somalia
Evolution and global spatio-temporal spread of Coxsackievirus A6
Modelling the spread of drug resistance to a key malaria prevention drug in children
Are complex models necessary to realistically measure epidemic spread?
Quantifying the contribution of surveillance datastreams in informing key epidemiological drivers of the Covid-19 pandemic in the UK
Applying machine learning to the automated interpretation of genomic epidemiology data
Towards HIV elimination: a mathematical model-based examination of transmission in Manicaland, Zimbabwe
The potential impact of HIV pre-exposure prophylaxis (PrEP) on HIV outcomes in Western Africa: a mathematical modelling analysis
Microbiome in Health and Disease
One-Health surveillance of emerging antifungal resistance across a UK cohort of farms, homes and green-waste recyclers
Optimisation of storage and transportation of high throughput DESI swab testing of vaginal dysbiosis.
Exploring the impact of Mediterranean and Western diet on the gut bacterial metabolism
Westernisation of the faecal metabolic profiles
Measuring bacterial sugar nutrients in faecal samples by LC-MS/MS to assess the risk of pathogenic gut colonisation upon administration of antibiotics
The role of cervicovaginal microbiome on cervical carcinogenesis
Testing and developing novel drying matrices for Intestinal Microbiota Transplant capsules.
Can stabilized stool samples be used for bacterial culture, basic proteomics and clinical diagnostics?
Molecular Basis of Human Disease
How does proteostasis restrict toxic protein aggregates from damaging the cell?
The role of Mannose-6-phosphate receptor (M6PR) in human pancreatic β-cells
Investigating the role of CD63 in human adipose stem cells
How the bacterial type II secretion system powers toxin release
The Tight adherence molecular machine builds pili and drives bacterial pathogenesis
Novel neuromodulators from the gut microbiome
Biosensor screening using a bacterial synthetic memory circuit
Spatial biosensor development for the inflammatory biomarker sialic acid
Using wildDISCO to characterise disruption of sleep-wake cycles in Alzheimer's disease
Investigating the impact of genomic diversity on cell wall chemistry in Aspergillus fumigatus
Respiratory and Cardiovascular Science
Characterisation of lung pericytes and how inflammation can shape them
The role of mitochondrial dynamics in cardiac inflammatory phenotype
Identification of the miRNA markers of cardiac fibrosis from heart failure patients using new nanopore technology
Investigating the role of MAP4 and microtubule dynamics in heart failure.
How does PDE4B involve in the β2AR-cAMP compartmentation during hypoosmotic stress?
A systematic review and meta-analysis of trial evidence evaluating behavioural interventions to reduce asthma symptoms
Interactions of Immune Sub-populations with Cardiac Cell Types in Post-Infarct Human and Mouse Hearts
Role of sympathetic neurons in regulating cardiomyocyte conductance and electrical properties.
Aspergillus-specific immune responses in chronic respiratory disease
Characterization of MSC-derived exosomes from 3D culture systems
You can download a full list of the projects and supervisors for each stream below.