@article{Mearkle:2017:10.2807/1560-7917.ES.2017.22.19.30532,
author = {Mearkle, R and Saavedra-Campos, M and Lamagni, T and Usdin, M and Coelho, J and Chalker, V and Sriskandan, S and Cordery, R and Rawlings, C and Balasegaram, S},
doi = {10.2807/1560-7917.ES.2017.22.19.30532},
journal = {Eurosurveillance},
title = {Household transmission of invasive group A Streptococcus infections in England: a population-based study, 2009, 2011 to 13},
url = {http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30532},
volume = {22},
year = {2017}
}

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TY  - JOUR
AB  - Invasive group A streptococcal infection has a 15% case fatality rateand a risk of secondary transmission.This retrospective studyusedtwo national data sourcesfrom England; enhanced surveillance (2009) and a case management system(2011-13) to identify clustersof severegroup A streptococcaldisease.24household pairswere identified.The median onset interval between cases was 2 days (range 0-28)with simultaneous onset in 8pairs.The attack rate during the 30 days after first exposure to aprimarycase was 4520per 100000 person-years at risk (95% CI2900-6730)a 1940(1240-2880) fold elevation over the background incidence.The theoretical number needed to treat (NNT)to prevent one secondary case using antibiotic prophylaxis was 271(194-454)overall,50formother-neonate pairs (27-393) and 82for couples aged75 yearsand over(46-417). Whilst a dramatic increased risk of infection was noted in all household contacts, increased risk was greatest for mother-neonatepairs and couplesaged 75 and over, suggesting targeted prophylaxis could be considered.Offering prophylaxis is challenging due to the shorttime interval between casesemphasising the importance of immediate notificationand assessment of contacts.
AU  - Mearkle,R
AU  - Saavedra-Campos,M
AU  - Lamagni,T
AU  - Usdin,M
AU  - Coelho,J
AU  - Chalker,V
AU  - Sriskandan,S
AU  - Cordery,R
AU  - Rawlings,C
AU  - Balasegaram,S
DO  - 10.2807/1560-7917.ES.2017.22.19.30532
PY  - 2017///
SN  - 1560-7917
TI  - Household transmission of invasive group A Streptococcus infections in England: a population-based study, 2009, 2011 to 13
T2  - Eurosurveillance
UR  - http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30532
UR  - http://hdl.handle.net/10044/1/43572
VL  - 22
ER  - 

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