@article{Yates:2021:10.1186/s12879-021-06466-0,
author = {Yates, T and Zaccardi, F and Islam, N and Razieh, C and Gillies, CL and Lawson, CA and Chudasama, Y and Rowlands, A and Davies, MJ and Docherty, AB and Openshaw, PJM and Baillie, JK and Semple, MG and Khunti, K},
doi = {10.1186/s12879-021-06466-0},
journal = {BMC Infectious Diseases},
pages = {1--9},
title = {Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort},
url = {http://dx.doi.org/10.1186/s12879-021-06466-0},
volume = {21},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundAlthough age, obesity and pre-existing chronic diseases are established risk factors for COVID-19 outcomes, their interactions have not been well researched.MethodsWe used data from the Clinical Characterisation Protocol UK (CCP-UK) for Severe Emerging Infection developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC). Patients admitted to hospital with COVID-19 from 6th February to 12th October 2020 were included where there was a coded outcome following hospital admission. Obesity was determined by an assessment from a clinician and chronic disease by medical records. Chronic diseases included: chronic cardiac disease, hypertension, chronic kidney disease, chronic pulmonary disease, diabetes and cancer. Mutually exclusive categories of obesity, with or without chronic disease, were created. Associations with in-hospital mortality were examined across sex and age categories.ResultsThe analysis included 27,624 women with 6407 (23.2%) in-hospital deaths and 35,065 men with 10,001 (28.5%) in-hospital deaths. The prevalence of chronic disease in women and men was 66.3 and 68.5%, respectively, while that of obesity was 12.9 and 11.1%, respectively. Association of obesity and chronic disease status varied by age (p < 0.001). Under 50 years of age, obesity and chronic disease were associated with in-hospital mortality within 28 days of admission in a dose-response manner, such that patients with both obesity and chronic disease had the highest risk with a hazard ratio (HR) of in-hospital mortality of 2.99 (95% CI: 2.12, 4.21) in men and 2.16 (1.42, 3.26) in women compared to patients without obesity or chronic disease. Between the ages of 50–69 years, obesity and chronic disease remained associated with in-hospital COVID-19 mortality, but survival in those with obesity was similar to those with and without prevalent chronic disease. Beyond the age of 70 years in men and
AU  - Yates,T
AU  - Zaccardi,F
AU  - Islam,N
AU  - Razieh,C
AU  - Gillies,CL
AU  - Lawson,CA
AU  - Chudasama,Y
AU  - Rowlands,A
AU  - Davies,MJ
AU  - Docherty,AB
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Semple,MG
AU  - Khunti,K
DO  - 10.1186/s12879-021-06466-0
EP  - 9
PY  - 2021///
SN  - 1471-2334
SP  - 1
TI  - Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort
T2  - BMC Infectious Diseases
UR  - http://dx.doi.org/10.1186/s12879-021-06466-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000679717300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06466-0
UR  - http://hdl.handle.net/10044/1/91333
VL  - 21
ER  - 

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