@article{Kundu:2022:10.1038/s41467-021-27674-x,
author = {Kundu, R and Sam, Narean J and Wang, L and Fenn, J and Pillay, T and Derqui, N and Conibear, E and Koycheva, A and Davies, M and Tolosa-Wright, M and Hakki, S and Varro, R and McDermott, E and Hammett, S and Cutajar, J and Thwaites, R and Parker, E and Rosados, C and McClure, M and Tedder, R and Taylor, G and Dunning, J and Lalvani, A},
doi = {10.1038/s41467-021-27674-x},
journal = {Nature Communications},
title = {Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts},
url = {http://dx.doi.org/10.1038/s41467-021-27674-x},
volume = {13},
year = {2022}
}

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TY  - JOUR
AB  - Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure.  Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, we enumerate the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses. We observe higher frequencies of cross-reactive (p=0.0139), and nucleocapsid-specific (p=0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n=26), when compared with those who convert to PCR-positive (n=26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. Our results are thus consistent with pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
AU  - Kundu,R
AU  - Sam,Narean J
AU  - Wang,L
AU  - Fenn,J
AU  - Pillay,T
AU  - Derqui,N
AU  - Conibear,E
AU  - Koycheva,A
AU  - Davies,M
AU  - Tolosa-Wright,M
AU  - Hakki,S
AU  - Varro,R
AU  - McDermott,E
AU  - Hammett,S
AU  - Cutajar,J
AU  - Thwaites,R
AU  - Parker,E
AU  - Rosados,C
AU  - McClure,M
AU  - Tedder,R
AU  - Taylor,G
AU  - Dunning,J
AU  - Lalvani,A
DO  - 10.1038/s41467-021-27674-x
PY  - 2022///
SN  - 2041-1723
TI  - Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-27674-x
UR  - https://www.nature.com/articles/s41467-021-27674-x
UR  - http://hdl.handle.net/10044/1/93018
VL  - 13
ER  - 

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