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Cancer

Immune checkpoint therapies have revolutionized the treatment of multiple types of cancer, including melanoma, non-small cell lung cancer, kidney cancer and Hodgkin lymphoma. However, many other cancers are refractory to checkpoint therapies. Key areas of research are understanding how tumour-autonomous features (tumour genetics/epigenetics and metabolism) and the microbiome modify the immune microenvironment in solid malignancies. Chimaeric antigen receptor (CAR) T cell immunotherapy is used to treat childhood leukaemia and certain types of adult B cell lymphoma. There is a need to develop novel cell therapies for solid tumours, using genetically modified NK and iNKT cells. The participation in the Network of ICR groups from the CRUK Convergence Science Centre and groups from the Francis Crick Institute widens the potential scope for fundamental discovery in cancer immunology as well as clinical implementation of novel immuno-therapies.

Dr Holger Auner
Clinical Reader in Molecular Haemato-Oncology

Dr Axel Behrens
Scientific Director, ICR Imperial Convergence Science Centre

Dr Dominique Bonnet
Senior Group Leader - The Crick

Dr Dinis Calado
Group Leader - The Crick

Dr Francesca Ciccarelli
Group Leader (Secondment) - The Crick

Professor Julian Downward
Senior Group Leader; Associate Research Director - The Crick

Professor Guido Franzoso
Centre Co-Director, Chair in Inflammation and Signal Transduction

Dr Andrew Furness
Team Leader - ICR

Dr Marco Gerlinger
Team Leader - ICR

Professor Sadaf Ghaem-Maghami
Professor of Gynaecological Oncology

Dr Nadia Guerra
Senior Lecturer

Dr Paul Huang
Team Leader - ICR

Professor Clare Isacke
Team Leader - ICR

Professor Anastasios Karadimitris
Co-Director Centre for Haematology, Professor of Haematology

Dr Astero Klampatsa
Team Leader - ICR

Dr Vivian Li
Group Leader - The Crick

Professor Cristina Lo Celso
Co-Director Centre for Haematology & Prof Stem Cell Biology

Professor Chris Lord
Deputy Head of Division and Team Leader - ICR

Dr Ilaria Malanchi
Senior Group Leader - The Crick

Professor Iain McNeish
Chair in Oncology

Professor Pascal Meier
Team Leader - ICR

Professor Alan Melcher
Team Leader - ICR

Dr Ben O'Leary
Senior Researcher - ICR

Dr David Pinato
Clinical Senior Lecturer in Medical Oncology

Dr Caetano Reis e Sousa
Senior Group Leader - The Crick

Dr Anguraj Sadanandam
Team Leader - ICR

Dr Erik Sahai
Senior Group Leader; Assistant Research Director - The Crick

Dr Jessica Strid
Reader in Cellular Immunology

Professor Charles Swanton
Senior Group Leader - The Crick

Sir Richard Henry Treisman
Crick Director of Research

Dr Samra Turajlic
Clinical Science Group Leader - The Crick

Professor Nicholas Turner
Team Leader - ICR

Dr Erik Wennerberg
Team Leader - ICR

Dr Anna Wilkins
Senior Researcher - ICR

Professor Yinyin Yuan
Team Leader - ICR