In this section
@article{Malietzis:2015:10.1002/jso.23959,
author = {Malietzis, G and Lee, GH and Bernardo, D and Blakemore, AIF and Knight, SC and Moorghen, M and Al-Hassi, HO and Jenkins, JT},
doi = {10.1002/jso.23959},
journal = {Journal of Surgical Oncology},
pages = {86--92},
title = {The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer},
url = {http://dx.doi.org/10.1002/jso.23959},
volume = {112},
year = {2015}
}
TY - JOUR
AB - Background and ObjectivesThe host local immune response (LIR) to cancer is a determinant of cancer outcome. Regulation of this local response is largely achieved through chemokine synthesis from the tumor microenvironment such as C-Chemokine-Receptor-7 (CCR7). We examined the LIR measured as CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) and survival.MethodsA study of paraffin-embedded tissue specimens was carried out in 116 patients with non-metastatic CRC. CCR7 expression was determined by immunohistochemistry. Analysis of computer tomography scans was used to calculate BC parameters. Survival analyses and multivariate regression models were used.ResultsHigh CCR7+ cell density within the tumor stroma and at the margin was significantly associated with increased age, the presence of lymphovascular invasion, higher tumor stage, lymph node metastasis, high Klintrup-Makinen immune score, and myosteatosis. High CCR7+ cell density in the tumor margin was significantly associated with shorter disease-free (DFS) and overall survival (OS) (P < 0.001). This was also significantly associated with shorter survival in multivariate analysis (HR = 8.87; 95%CI [2.51–31.3]; P < 0.01 for OS and HR = 4.72; 95%CI (1.24–12.9); P = 0.02 for DFS).ConclusionsOur results suggest that a specific immune microenvironment may be associated with altered host's BC and tumor behavior, and that CCR7 may serve as a novel prognostic biomarker.
AU - Malietzis,G
AU - Lee,GH
AU - Bernardo,D
AU - Blakemore,AIF
AU - Knight,SC
AU - Moorghen,M
AU - Al-Hassi,HO
AU - Jenkins,JT
DO - 10.1002/jso.23959
EP - 92
PY - 2015///
SN - 1096-9098
SP - 86
TI - The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer
T2 - Journal of Surgical Oncology
UR - http://dx.doi.org/10.1002/jso.23959
UR - http://hdl.handle.net/10044/1/27620
VL - 112
ER -
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