Publications

Citation

BibTex format

@article{Malietzis:2016:10.1007/s13277-016-5009-y,
author = {Malietzis, G and Lee, GH and Al-Hassi, HO and Bernardo, D and Blakemore, AI and Kennedy, RH and Moorghen, M and Jenkins, JT and Knight, SC},
doi = {10.1007/s13277-016-5009-y},
journal = {Tumor Biology},
pages = {11359--11364},
title = {Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer},
url = {http://dx.doi.org/10.1007/s13277-016-5009-y},
volume = {37},
year = {2016}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dendritic cells (DCs) are antigen-presenting cells that can acquire tumour antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a cause for tumours escaping immune surveillance, but few studies investigate the impact of other body composition parameters. We examined the relationship of DC phenotype with computer tomography (CT)-defined parameters in patients with colorectal cancer (CRC). DCs were identified within peripheral blood mononuclear cells by flow cytometry as HLA-DR positive and negative for markers of other cell lineages in 21 patients. Analysis of CT scans was used to calculate lumbar skeletal muscle index (LSMI) and mean muscle attenuation (MA). Positive correlation between the LSMI and expression of CD40 in all DCs (r = 0.45; p = 0.04) was demonstrated. The MA was positively correlated with scavenger receptor CD36 [all DCs (r = 0.60; p = 0.01) and myeloid DCs (r = 0.63; p < 0.01)]. However, the MA was negatively correlated with CCR7 expression in all DCs (r = −0.46, p = 0.03.) and with CD83 [all DCs (r = −0.63; p = 0.01) and myeloid DCs (r = −0.75; p < 0.01)]. There were no relationships between the fat indexes and the DC phenotype. These results highlight a direct relationship between muscle depletion and changes in stimulatory, migratory and fatty acid-processing potential of DC in patients with CRC.
AU  - Malietzis,G
AU  - Lee,GH
AU  - Al-Hassi,HO
AU  - Bernardo,D
AU  - Blakemore,AI
AU  - Kennedy,RH
AU  - Moorghen,M
AU  - Jenkins,JT
AU  - Knight,SC
DO  - 10.1007/s13277-016-5009-y
EP  - 11364
PY  - 2016///
SN  - 1423-0380
SP  - 11359
TI  - Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer
T2  - Tumor Biology
UR  - http://dx.doi.org/10.1007/s13277-016-5009-y
UR  - http://hdl.handle.net/10044/1/31513
VL  - 37
ER  -

Download

Publications

Citation

BibTex format

RIS format (EndNote, RefMan)

General enquiries

Address

Find us on social media