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  • Journal article
    Al-Hassi HO, Bernardo D, Murugananthan AU, Mann ER, English NR, Jones A, Kamm MA, Arebi N, Hart AL, Blakemore AI, Stagg AJ, Knight SCet al., 2013,

    A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

    , Mucosal Immunology, Vol: 6, Pages: 751-761, ISSN: 1933-0219

    Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3beta in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation.
  • Conference paper
    Yassin NA, Al-Hassi OH, Lee GH, Maleitzis G, Tozer P, Mann E, Bernardo D, Phillips RK, Knight SC, Hart ALet al., 2013,

    The Immune Cell Activation and Homing Profile of Dendritic Cells in Fistulating Perianal Crohn's Disease

    , DDW
  • Conference paper
    Yassin NA, Al-Hassi H, Lee GH, Malietzis G, Tozer P, Bernardo-Ordiz D, Mann E, Phillips RKS, Knight S, Hart ALet al., 2013,

    The aetiology, immune activation and homing profile of dendritic cells in fistulating perianal Crohn's disease

    , European Crohn's and Colitis Organisation
  • Journal article
    Peake STC, Bernardo D, Mann ER, Landy J, Al-Hassi HO, Knight SC, Hart ALet al., 2013,

    Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?

    , J Crohns Colitis
  • Journal article
    Bernardo D, Mann ER, Al-Hassi HO, English NR, Man R, Lee GH, Ronde E, Landy J, Peeake STC, Hart AL, Knight SCet al., 2013,

    Lost therapeutic potential of monocyte-derived DC through lost tissue homing; stable restoration of gut specificity with retinoic acid

    , Clinical Experimental Immunology
  • Journal article
    Mann ER, Landy J, Bernardo D, Peake STC, Hart AL, Al-Hassi HO, Knight SCet al., 2013,

    Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men

    , Immunology Letters
  • Journal article
    Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ, Knight SCet al., 2012,

    Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease

    , CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 170, Pages: 122-130, ISSN: 0009-9104
  • Conference paper
    Rahbour G, Al-Hassi HO, Hart AL, Ullah MR, Gabe SM, Knight SC, Warusavitarne J, Vaizey CJet al., 2012,

    Tumour necrosis factor alpha in non-inflammatory bowel disease enterocutaneous fistulas prospective study

    , European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 536-537, ISSN: 0019-2805
  • Journal article
    Landy J, Al-Hassi HO, Peake ST, English N, Ciclitira PJ, Nicholls RJ, Clark SK, Knight SC, Hart ALet al., 2012,

    INAPPROPRIATE INFLAMMATORY RESPONSES IN THE ILEUM OF ULCERATIVE COLITIS PATIENTS

    , GUT, Vol: 61, Pages: A222-A222, ISSN: 0017-5749
  • Journal article
    Murugananthan AU, Bernardo DO, Tozer P, Hart AL, Knight SC, Whelan K, Arebi N, Al-Hassi HOet al., 2012,

    CLINICAL RISK FACTORS FOR CROHN'S DISEASE POSTOPERATIVE RECURRENCE ARE REFLECTED IN ALTERATIONS IN MUCOSALLY ADHERENT MICROBIOTA AT SURGICAL RESECTION

    , GUT, Vol: 61, Pages: A168-A168, ISSN: 0017-5749

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