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  • Conference paper
    Mann ER, Bernardo D, Al-Hassi HO, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ, Knight SCet al., 2010,

    Human dendritic cell function is dependent on tissue of residence

    , Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 40-40, ISSN: 0019-2805
  • Conference paper
    Bernardo D, Al-Hassi HO, Mann ER, Tee CT, Murugananthan AU, Milestone AN, Hart AL, Knight SCet al., 2010,

    Monocyte-derived dendritic cells lack the expression of homing markers although retinoic acid generates functional gut-homing dendritic cells

    , Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 88-89, ISSN: 0019-2805
  • Conference paper
    Mann ER, Bernardo D, Al-Hassi HO, Tee CT, Murugananthan AU, Thomas L, Hart AL, Knight SCet al., 2010,

    Probiotic bacteria <i>Lactobacillus casei Shirota</i> modulates human dendritic cell phenotype and function

    , Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 129-129, ISSN: 0019-2805
  • Journal article
    Hart AL, Ng SC, Mann E, Al-Hassi HO, Bernardo D, Knight SCet al., 2010,

    Homing of Immune Cells: Role in Homeostasis and Intestinal Inflammation

    , INFLAMMATORY BOWEL DISEASES, Vol: 16, Pages: 1969-1977, ISSN: 1078-0998
  • Journal article
    Ng SC, Plamondon S, Kamm MA, Hart AL, Al-Hassi HO, Guenther T, Stagg AJ, Knight SCet al., 2010,

    Immunosuppressive Effects via Human Intestinal Dendritic Cells of Probiotic Bacteria and Steroids in the Treatment of Acute Ulcerative Colitis

    , INFLAMMATORY BOWEL DISEASES, Vol: 16, Pages: 1286-1298, ISSN: 1078-0998
  • Journal article
    Price CL, Hassi HO, English NR, Blakemore AI, Stagg AJ, Knight SCet al., 2010,

    Methylglyoxal modulates immune responses: relevance to diabetes

    , Journal of Cellular and Molecular Medicine, Vol: 14, Pages: 1806-1815, ISSN: 1582-1838

    Increased methylglyoxal (MG) concentrations and formation of advanced glycation end-products (AGEs) are major pathways of glycaemic damage in diabetes, leading to vascular and neuronal complications. Diabetes patients also suffer increased susceptibility to many common infections, the underlying causes of which remain elusive. We hypothesized that immune glycation damage may account for this increased susceptibility. We previously showed that the reaction mixture (RM) for MG glycation of peptide blocks up regulation of CD83 in myeloid cells and inhibits primary stimulation of T cells. Here, we continue to investigate immune glycation damage, assessing surface and intracellular cytokine protein expression by flow cytometry, T-cell proliferation using a carboxyfluorescein succinimidyl ester assay, and mRNA levels by RT-PCR. We show that the immunomodulatory component of this RM was MG itself, with MG alone causing equivalent block of CD83 and loss of primary stimulation. Block of CD83 expression could be reversed by MG scavenger N-acetyl cysteine. Further, MG within RM inhibited stimulated production of interleukin (IL)-10 protein from myeloid cells plus interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha from T cells. Loss of IL-10 and IFN-gamma was confirmed by RT-PCR analysis of mRNA, while TNF-alpha message was raised. Loss of TNF-alpha protein was also shown by ELISA of culture supernatants. In addition, MG reduced major histocompatibility complex (MHC) class I expression on the surface of myeloid cells and increased their propensity to apoptose. We conclude that MG is a potent suppressor of myeloid and T-cell immune function and may be a major player in diabetes-associated susceptibility to infection.
  • Conference paper
    Murugananthan AU, Bernardo DO, Tee CT, Arebi N, Knight SC, Al-Hassi HOet al., 2010,

    LOSS OF TLR 2 AND 4 ON ILEAL PLASMACYTOID DENDRITIC CELLS IN POST-OPERATIVE CROHN'S DISEASE PATIENTS

    , Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A63-A63, ISSN: 0017-5749
  • Conference paper
    Milestone AN, Bernado-Ordiz D, English NR, Mann ER, Hart AL, Knight SC, Al-Hassi HOet al., 2010,

    THE IMMUNOMODULATORY EFFECTS OF VITAMIN D ON LOW-DENSITY CELLS AND MONOCYTE-DERIVED DENDRITIC CELLS FROM HUMAN PERIPHERAL BLOOD IN VITRO

    , Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A62-A63, ISSN: 0017-5749
  • Conference paper
    Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K, Lindsay JOet al., 2010,

    NO CLINICAL BENEFIT OF PREBIOTICS IN THE TREATMENT OF ACTIVE CROHN'S DISEASE: A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL

    , Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A1-A2, ISSN: 0017-5749
  • Conference paper
    Benjamin JL, Koutsoumpas A, Hedin CRH, Ng SC, Prescott NJ, Pessoa-Lopes P, Mathew CG, Kamm MA, Hart AL, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Lindsay JO, Whelan Ket al., 2010,

    DEMOGRAPHIC, CLINICAL AND GENETIC FACTORS ASSOCIATED WITH DYSBIOSIS IN PATIENTS WITH ACTIVE CROHN'S DISEASE

    , Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A5-A5, ISSN: 0017-5749

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