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  • Journal article
    McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Harrsi HO, English NR, Murray C, Lambert J, Knight SC, Stagg AJet al., 2005,

    Enhanced CD1 expression by activated human respiratory tract dendritic cells in atopic asthma: a role for lipid antigen in allergen tolerance?

    , IMMUNOLOGY, Vol: 116, Pages: 22-22, ISSN: 0019-2805
  • Journal article
    Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, Kamm MA, Stagg AJet al., 2005,

    Characteristics of intestinal dendritic cells in inflammatory bowel diseases

    , GASTROENTEROLOGY, Vol: 129, Pages: 50-65, ISSN: 0016-5085
  • Journal article
    Hart AL, Lammers K, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA, Knight SC, Stagg AJet al., 2004,

    Modulation of human dendritic cell phenotype and function by probiotic bacteria

    , GUT, Vol: 53, Pages: 1602-1609, ISSN: 0017-5749
  • Journal article
    Stagg AJ, Hart AL, Knight SC, Kamm MAet al., 2004,

    Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity.

    , Best Pract Res Clin Gastroenterol, Vol: 18, Pages: 255-270, ISSN: 1521-6918

    Dendritic cells (DCs) are immunoregulatory antigen-presenting cells. DCs can be potent activators of naïve T cells and influence the generation and homing of effector lymphocytes; they can also induce regulatory mechanisms and maintain non-responsiveness. In part, these different outcomes are influenced by exposure of the DC to microbial products. The regulatory role of DCs is of particular importance at mucosal surfaces such as the intestine, where the immune system exists in intimate association with the external antigenic environment. Much of what we know about DCs has come from studies on the cells outside the gastrointestinal tract but information about gut DCs and their contribution to the specialized immune environment of the gut is now emerging. Here, we review current knowledge on gut DCs, suggest models for interactions between DCs and the commensal microflora in health and disease, and discuss gut DCs as targets for probiotic therapies.
  • Conference paper
    Hart AL, Al-Hassi HO, Kamm MA, Knight SC, Stagg AJet al., 2004,

    Toll like receptors 2 and 4 are upregulated on human lamina propria dendritic cells in intestinal inflammation

    , Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A3-A3, ISSN: 0017-5749
  • Conference paper
    Lammers KM, Hart AL, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA, Knight SC, Stagg AJet al., 2004,

    DNA derived from probiotic bacteria modulates human dendritic cell phenotype and function

    , Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A65-A65, ISSN: 0017-5749
  • Conference paper
    Gallagher MC, North ME, Islam S, Knight SC, Phillips RKSet al., 2004,

    Dendritic cells from patients with familial adenomatous polyposis and colorectal cancer display an immature phenotype - A mechanism of immune dysregulation permissive to cancer development

    , Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A120-A120, ISSN: 0017-5749
  • Conference paper
    Hart AL, Al-Hassi HO, Kamm MA, Knight SC, Stagg AJet al., 2004,

    Dendritic cells may drive proinflammatory T cell immune responses in Crohn's disease by production of IL-12 and IL-6

    , Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A97-A98, ISSN: 0017-5749
  • Journal article
    Hart AL, Kamm MA, Knight SC, Stagg AJet al., 2004,

    Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls

    , CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 135, Pages: 137-145, ISSN: 0009-9104
  • Journal article
    AL Hart, MA Kamm, SC Knight, AJ Stagget al., 2004,

    Prospective evaluation of intestinal homing memory T cells in ulcerative colitis

    , Inflam. Bowel Dis, Vol: 10, Pages: 496-503

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