@article{Brial:2018:10.1007/s00018-018-2901-1,
author = {Brial, F and Le, Lay A and Dumas, M-E and Gauguier, D},
doi = {10.1007/s00018-018-2901-1},
journal = {Cellular and Molecular Life Sciences},
pages = {3977--3990},
title = {Implication of gut microbiota metabolites in cardiovascular and metabolic diseases},
url = {http://dx.doi.org/10.1007/s00018-018-2901-1},
volume = {75},
year = {2018}
}

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TY  - JOUR
AB  - Evidence from the literature keeps highlighting the impact of mutualistic bacterial communities of the gut microbiota on human health. The gut microbita is a complex ecosystem of symbiotic bacteria which contributes to mammalian host biology by processing, otherwise, indigestible nutrients, supplying essential metabolites, and contributing to modulate its immune system. Advances in sequencing technologies have enabled structural analysis of the human gut microbiota and allowed detection of changes in gut bacterial composition in several common diseases, including cardiometabolic disorders. Biological signals sent by the gut microbiota to the host, including microbial metabolites and pro-inflammatory molecules, mediate microbiome–host genome cross-talk. This rapidly expanding line of research can identify disease-causing and disease-predictive microbial metabolite biomarkers, which can be translated into novel biodiagnostic tests, dietary supplements, and nutritional interventions for personalized therapeutic developments in common diseases. Here, we review results from the most significant studies dealing with the association of products from the gut microbial metabolism with cardiometabolic disorders. We underline the importance of these postbiotic biomarkers in the diagnosis and treatment of human disorders.
AU  - Brial,F
AU  - Le,Lay A
AU  - Dumas,M-E
AU  - Gauguier,D
DO  - 10.1007/s00018-018-2901-1
EP  - 3990
PY  - 2018///
SN  - 1420-682X
SP  - 3977
TI  - Implication of gut microbiota metabolites in cardiovascular and metabolic diseases
T2  - Cellular and Molecular Life Sciences
UR  - http://dx.doi.org/10.1007/s00018-018-2901-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445868900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68188
VL  - 75
ER  - 

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