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Conference paperGhani R, Gan C, Mullish BH, et al., 2019,
P13-2 Prevalence of recurrent Extended Spectrum Beta-Lactamase (ESBL) urinary tract infections (UTIs) in patients within a Urology service and introducing the concept of Faecal Microbiota Transplantation (FMT) as a treatment modality
, British Association of Urological Surgeons Annual Scientific Meeting, Publisher: SAGE Publications, Pages: 83-85, ISSN: 2051-4158 -
Journal articleAllegretti JR, Kassam Z, Chiang AL, et al., 2019,
621 – Fecal microbiota transplantation for the treatment of obesity: A randomized, placebo-controlled pilot trial
, Gastroenterology, Vol: 156, Pages: S-129-S-129, ISSN: 0016-5085 -
Journal articleAllegretti JR, Hurtado J, Carrellas M, et al., 2019,
7 – The icon study: Inflammatory bowel disease and recurrent clostridium difficile infection: Outcomes after fecal microbiota transplantation
, Gastroenterology, Vol: 156, Pages: S-2-S-3, ISSN: 0016-5085 -
Journal articleChurchward MA, Michaud ER, Blanco JM, et al., 2019,
Sa1924 – Effect of short chain fatty acids on gut-brain axis using a microglial cell model
, Gastroenterology, Vol: 156, Pages: S-455-S-455, ISSN: 0016-5085 -
Journal articleMcDonald JA, Perez JL, Mullish BH, et al., 2019,
Mo1953 – Growth inhibition of clostridioides difficile by short and medium chain fatty acids
, Gastroenterology, Vol: 156, Pages: S-898-S-898, ISSN: 0016-5085 -
Journal articleAbdul Rahim MBH, Chilloux J, Martinez-Gili L, et al., 2019,
Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles
, Acta Diabetologica, Vol: 56, Pages: 493-500, ISSN: 0940-5429The human gut is a home for more than 100 trillion bacteria, far more than all other microbial populations resident on the body's surface. The human gut microbiome is considered as a microbial organ symbiotically operating within the host. It is a collection of different cell lineages that are capable of communicating with each other and the host and has an ability to undergo self-replication for its repair and maintenance. As the gut microbiota is involved in many host processes including growth and development, an imbalance in its ecological composition may lead to disease and dysfunction in the human. Gut microbial degradation of nutrients produces bioactive metabolites that bind target receptors, activating signalling cascades, and modulating host metabolism. This review covers current findings on the nutritional and pharmacological roles of selective gut microbial metabolites, short-chain fatty acids, methylamines and indoles, as well as discussing nutritional interventions to modulate the microbiome.
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Conference paperGhani R, Gan C, Mullish B, et al., 2019,
MP71-15 Prevalence of recurrent extended-spectrum beta-lactamase (ESBL) urinary tract infections (UTIs) in patients within a urology service. Introducing the concept of Faecal Microbiota transplantation (FMT) as a treatment modality.
, AUA 2019, Publisher: Elsevier, ISSN: 0022-5347 -
Journal articleAhmed B, Cox M, Cuthbertson L, et al., 2019,
Longitudinal development of the airway microbiota in infants with cystic fibrosis
, Scientific Reports, Vol: 9, ISSN: 2045-2322The pathogenesis of airway infection in cystic fibrosis (CF) is poorly understood. We performed a longitudinal study coupling clinical information with frequent sampling of the microbiota to identify changes in the airway microbiota in infancy that could underpin deterioration and potentially be targeted therapeutically. Thirty infants with CF diagnosed on newborn screening (NBS) were followed for up to two years. Two hundred and forty one throat swabs were collected as a surrogate for lower airway microbiota (median 35 days between study visits) in the largest longitudinal study of the CF oropharyngeal microbiota. Quantitative PCR and Illumina sequencing of the 16S rRNA bacterial gene were performed. Data analyses were conducted in QIIME and Phyloseq in R. Streptococcus spp. and Haemophilus spp. were the most common genera (55% and 12.5% of reads respectively) and were inversely related. Only beta (between sample) diversity changed with age (Bray Curtis r2 = 0.15, P = 0.03). Staphylococcus and Pseudomonas were rarely detected. These results suggest that Streptococcus spp. and Haemophilus spp., may play an important role in early CF. Whether they are protective against infection with more typical CF micro-organisms, or pathogenic and thus meriting treatment needs to be determined.
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Conference paperOvadia C, Perdones-Montero A, Mullish B, et al., 2019,
Ursodeoxycholic acid treatment of cholestatic pregnancy can alter the gut microbiota to enhance bile acid modification and production of metabolically-active secondary bile acids - an explanation for 'responders' and 'non-responders'?
, Publisher: WILEY, Pages: 17-17, ISSN: 1470-0328 -
Journal articleMcilroy JR, Segal JP, Mullish BH, et al., 2019,
Current and future targets for faecal microbiota transplantation
, Human Microbiome Journal, Vol: 11, Pages: 100045-100045, ISSN: 2452-2317
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