@article{Venkatesh:2014:10.1016/j.immuni.2014.06.014,
author = {Venkatesh, M and Mukherjee, S and Wang, H and Li, H and Sun, K and Benechet, AP and Qiu, Z and Maher, L and Redinbo, MR and Phillips, RS and Fleet, JC and Kortagere, S and Mukherjee, P and Fasano, A and Le, Ven J and Nicholson, JK and Dumas, ME and Khanna, KM and Mani, S},
doi = {10.1016/j.immuni.2014.06.014},
journal = {Immunity},
pages = {296--310},
title = {Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the Xenobiotic sensor PXR and toll-like receptor 4},
url = {http://dx.doi.org/10.1016/j.immuni.2014.06.014},
volume = {41},
year = {2014}
}

Download

TY  - JOUR
AB  - Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR). Indole 3-propionic acid (IPA), in the context of indole, is a ligand for PXR in vivo, and IPA downregulated enterocyte TNF-α while it upregulated junctional protein-coding mRNAs. PXR-deficient (Nr1i2−/−) mice showed a distinctly “leaky” gut physiology coupled with upregulation of the Toll-like receptor (TLR) signaling pathway. These defects in the epithelial barrier were corrected in Nr1i2−/−Tlr4−/− mice. Our results demonstrate that a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4.
AU  - Venkatesh,M
AU  - Mukherjee,S
AU  - Wang,H
AU  - Li,H
AU  - Sun,K
AU  - Benechet,AP
AU  - Qiu,Z
AU  - Maher,L
AU  - Redinbo,MR
AU  - Phillips,RS
AU  - Fleet,JC
AU  - Kortagere,S
AU  - Mukherjee,P
AU  - Fasano,A
AU  - Le,Ven J
AU  - Nicholson,JK
AU  - Dumas,ME
AU  - Khanna,KM
AU  - Mani,S
DO  - 10.1016/j.immuni.2014.06.014
EP  - 310
PY  - 2014///
SN  - 1074-7613
SP  - 296
TI  - Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the Xenobiotic sensor PXR and toll-like receptor 4
T2  - Immunity
UR  - http://dx.doi.org/10.1016/j.immuni.2014.06.014
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341455300016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1074761314002362?via%3Dihub
VL  - 41
ER  - 

Download