@article{Farrer:2017:10.1038/ncomms14742,
author = {Farrer, RA and Martel, A and Verbrugghe, E and Abouelleil, A and Ducatelle, R and Longcore, JE and James, TY and Pasmans, F and Fisher, MC and Cuomo, CA},
doi = {10.1038/ncomms14742},
journal = {NATURE COMMUNICATIONS},
pages = {1--11},
title = {Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi},
url = {http://dx.doi.org/10.1038/ncomms14742},
volume = {8},
year = {2017}
}

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TY  - JOUR
AB  - To understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions of protease and cell wall gene families, while divergent infection strategies are linked to radiations of lineage-specific gene families. By comparing the host–pathogen response to infection for both pathogens, we illuminate the traits that underpin a strikingly different immune response within a shared host species. Our results show that, despite commonalities that promote infection, specific gene-family radiations contribute to distinct infection strategies. The breadth and evolutionary novelty of candidate virulence factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent incipient loss of biodiversity.
AU  - Farrer,RA
AU  - Martel,A
AU  - Verbrugghe,E
AU  - Abouelleil,A
AU  - Ducatelle,R
AU  - Longcore,JE
AU  - James,TY
AU  - Pasmans,F
AU  - Fisher,MC
AU  - Cuomo,CA
DO  - 10.1038/ncomms14742
EP  - 11
PY  - 2017///
SN  - 2041-1723
SP  - 1
TI  - Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi
T2  - NATURE COMMUNICATIONS
UR  - http://dx.doi.org/10.1038/ncomms14742
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396856000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/ncomms14742
UR  - http://hdl.handle.net/10044/1/46094
VL  - 8
ER  - 

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