@article{Dumas:2017:10.1016/j.celrep.2017.06.039,
author = {Dumas, M and Rothwell, AR and Hoyles, L and Aranias, T and Chilloux, J and Calderari, S and Noll, EM and Péan, N and Boulange, CL and Blancher, C and Barton, RH and Gu, Q and Fearnside, JF and Deshayes, C and Hue, C and Scott, J and Nicholson, JK and Gauguier, D},
doi = {10.1016/j.celrep.2017.06.039},
journal = {Cell Reports},
pages = {136--148},
title = {Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity and impaired glucose tolerance},
url = {http://dx.doi.org/10.1016/j.celrep.2017.06.039},
volume = {20},
year = {2017}
}

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TY  - JOUR
AB  - The influence of the gut microbiome on metabolic and behavioral traits is now widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine 1H NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n=50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic (obesity and glucose homeostasis) and behaviorial (anxiety and activity) outcomes with 94-100% accuracy. Some of these metabolites also modulate disease phenotypes, best illustrated by trimethylamine-N-oxide (TMAO), a product of microbial-host co-metabolism predicting future obesity, impaired glucose tolerance (IGT) and behavior, whilst reducing endoplasmic reticulum stress and lipogenesis in 3T3-L1 adipocytes. Chronic in vivo TMAO treatment limits IGT in HFD-fed mice and isolated pancreatic islets by increasing insulin secretion. We highlight the prodromal potential of microbial metabolites to predict disease outcomes and their potential in shaping mammalian phenotypic heterogeneity.
AU  - Dumas,M
AU  - Rothwell,AR
AU  - Hoyles,L
AU  - Aranias,T
AU  - Chilloux,J
AU  - Calderari,S
AU  - Noll,EM
AU  - Péan,N
AU  - Boulange,CL
AU  - Blancher,C
AU  - Barton,RH
AU  - Gu,Q
AU  - Fearnside,JF
AU  - Deshayes,C
AU  - Hue,C
AU  - Scott,J
AU  - Nicholson,JK
AU  - Gauguier,D
DO  - 10.1016/j.celrep.2017.06.039
EP  - 148
PY  - 2017///
SN  - 2211-1247
SP  - 136
TI  - Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity and impaired glucose tolerance
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2017.06.039
UR  - http://hdl.handle.net/10044/1/49234
VL  - 20
ER  - 

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