@article{Dos:2018:10.1111/1471-0528.15397,
author = {Dos, Santos F and Drymiotou, S and Antequera, A and Mol, BW and Gale, C and Devane, D and Van't, Hooft J and Johnson, MJ and Hogg, M and Thangaratinam, S},
doi = {10.1111/1471-0528.15397},
journal = {BJOG: An International Journal of Obstetrics and Gynaecology},
pages = {1673--1680},
title = {Development of a core outcome set for trials on induction of labour (COSIOL): an international multi-stakeholder Delphi study},
url = {http://dx.doi.org/10.1111/1471-0528.15397},
volume = {125},
year = {2018}
}

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TY  - JOUR
AB  - OBJECTIVE: To develop a set of core outcomes to be minimally reported in trials on induction of labour. DESIGN: Two-round Delphi survey and consensus meeting. POPULATION: Four Stakeholder groups: midwives, obstetricians, neonatologists, and women's representatives. METHODS: Protocol registered with COMET (registration number: 695). Stakeholders rated reported outcomes for importance (1-limited to 9-critical). The median rating of each outcome was calculated. The consensus criteria to include outcomes were: ≥ 70% participants rated outcomes as critical and <15% rated outcomes as limited importance. Outcomes that did not achieve consensus were taken to round two, and if still no consensus, to the final consensus meeting. MAIN OUTCOME MEASURES: Outcomes in trials of induction of labour. RESULTS: Of the 159 invited participants, 54% (86/159) completed the first round, and 83% completed the second round (71/86). The core outcome set included 28 core outcomes in four domains: Short-term maternal outcomes (n=18) - cardio-respiratory arrest, damage to internal organs, death, haemorrhage, hysterectomy, infection, intensive care admission, length of hospital stay, mode of delivery, need for more than one induction agent, oxytocin augmentation, postnatal depression, pulmonary embolus, satisfaction with care, stroke, time from induction to delivery, uterine hyperstimulation, uterine scar dehiscence/rupture; Short-term offspring outcomes (n=8) - admission to the neonatal unit, birth trauma, death, hypoxic ischaemic encephalopathy/need for therapeutic hypothermia, meconium aspiration syndrome, need for respiratory support, infection, seizures; Long-term maternal outcomes (n=1) - operative pelvic floor repair; Long-term offspring outcomes (n=1) - disability including neurodevelopmental delay. CONCLUSION: Trials on induction of labour should include this core outcome set to standardise reporting. This article is protected by copyright. All rights reserved.
AU  - Dos,Santos F
AU  - Drymiotou,S
AU  - Antequera,A
AU  - Mol,BW
AU  - Gale,C
AU  - Devane,D
AU  - Van't,Hooft J
AU  - Johnson,MJ
AU  - Hogg,M
AU  - Thangaratinam,S
DO  - 10.1111/1471-0528.15397
EP  - 1680
PY  - 2018///
SN  - 1470-0328
SP  - 1673
TI  - Development of a core outcome set for trials on induction of labour (COSIOL): an international multi-stakeholder Delphi study
T2  - BJOG: An International Journal of Obstetrics and Gynaecology
UR  - http://dx.doi.org/10.1111/1471-0528.15397
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29981523
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.15397
UR  - http://hdl.handle.net/10044/1/61610
VL  - 125
ER  - 

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