@article{Parkinson:2019:10.1038/s41390-019-0709-9,
author = {Parkinson, JRC and Emsley, R and Adkins, JLT and Longford, N and Ozanne, SE and Holmes, E and Modi, N},
doi = {10.1038/s41390-019-0709-9},
journal = {Pediatric Research},
pages = {1005--1010},
title = {Clinical and molecular evidence of accelerated ageing following very preterm birth},
url = {http://dx.doi.org/10.1038/s41390-019-0709-9},
volume = {87},
year = {2019}
}

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TY  - JOUR
AB  - BACKGROUND: The mechanisms responsible for the associations between very preterm birth and a higher risk of poor cardiovascular and metabolic health in adult life are unknown. METHODS: Here, we compare the clinical and molecular phenotypes of healthy, normal-weight young adults (18-27 years), born very preterm (<33 weeks gestational age (GA)) and at full-term (37-42 weeks GA). Outcomes included whole-body MRI, hepatic and muscle 1H MRS, blood pressure measurements and telomere length. RESULTS: We recruited 156 volunteers, 69 preterm (45 women; 24 men) and 87 born at full-term (45 women; 42 men). Preterm individuals had a significantly altered blood pressure profile, including higher systolic blood pressure (SBP mmHg: preterm men 133.4 ± 10.1, term men 23.0 ± 6.9; preterm women 124.3 ± 7.1, term women 118.4 ± 8.0, p < 0.01 for all). Furthermore, preterm men had fewer long telomeres (145-48.5 kb: preterm men 14.1 ± 0.9%, term men 17.8 ± 1.1%, p < 0.05; 48.5-8.6 kb: preterm men 28.2 ± 2.6, term men 37.0 ± 2.4%, p < 0.001) and a higher proportion of shorter telomeres (4.2-1.3 kb: preterm men 40.4 ± 3.5%, term men 29.9 ± 3.2%, p < 0.01). CONCLUSION: Our data indicate that healthy young adults born very preterm manifest clinical and molecular evidence of accelerated ageing.
AU  - Parkinson,JRC
AU  - Emsley,R
AU  - Adkins,JLT
AU  - Longford,N
AU  - Ozanne,SE
AU  - Holmes,E
AU  - Modi,N
DO  - 10.1038/s41390-019-0709-9
EP  - 1010
PY  - 2019///
SN  - 0031-3998
SP  - 1005
TI  - Clinical and molecular evidence of accelerated ageing following very preterm birth
T2  - Pediatric Research
UR  - http://dx.doi.org/10.1038/s41390-019-0709-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31812156
UR  - https://www.nature.com/articles/s41390-019-0709-9
UR  - http://hdl.handle.net/10044/1/76188
VL  - 87
ER  - 

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