@article{Gale:2021:10.1016/S2352-4642(21)00026-2,
author = {Gale, C and Longford, NT and Jeyakumaran, D and Ougham, K and Battersby, C and Ojha, S and Dorling, J},
doi = {10.1016/S2352-4642(21)00026-2},
journal = {The Lancet Child and Adolescent Health},
pages = {408--416},
title = {Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study},
url = {http://dx.doi.org/10.1016/S2352-4642(21)00026-2},
volume = {5},
year = {2021}
}

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TY  - JOUR
AB  - Background:Therapeutic hypothermia is standard of care in high-income countries for babies born with signs of hypoxic ischaemic encephalopathy, but optimal feeding during treatment is uncertain and practice is variable. This study aimed to assess the association between feeding during therapeutic hypothermia and clinically important outcomes.Methods:We did a population-level retrospective cohort study using the UK National Neonatal Research Database. We included all babies admitted to National Health Service neonatal units in England, Scotland, and Wales between Jan 1, 2010, and Dec 31, 2017, who received therapeutic hypothermia for 72 h or died during this period. For analysis, we created matched groups using propensity scores and compared outcomes in babies who were fed versus unfed enterally during therapeutic hypothermia. The primary outcome was severe necrotising enterocolitis, either confirmed at surgery or causing death. Secondary outcomes include pragmatically defined necrotising enterocolitis (a recorded diagnosis of necrotising enterocolitis in babies who received at least 5 consecutive days of antibiotics while also nil by mouth during their neonatal unit stay), late-onset infection (pragmatically defined as 5 consecutive days of antibiotic treatment commencing after day 3), survival to discharge, measures of breastmilk feeding, and length of stay in neonatal unit.Findings:6030 babies received therapeutic hypothermia, of whom 1873 (31·1%) were fed during treatment. Seven (0·1%) babies were diagnosed with severe necrotising enterocolitis and the number was too small for further analyses. We selected 3236 (53·7%) babies for the matched feeding analysis (1618 pairs), achieving a good balance for all recorded background variables. Pragmatically defined necrotising enterocolitis was rare in both groups (incidence 0·5%, 95% CI 0·2–0·9] in the fed group vs 1·1% [0·7–1·4] in the unfed grou
AU  - Gale,C
AU  - Longford,NT
AU  - Jeyakumaran,D
AU  - Ougham,K
AU  - Battersby,C
AU  - Ojha,S
AU  - Dorling,J
DO  - 10.1016/S2352-4642(21)00026-2
EP  - 416
PY  - 2021///
SN  - 2352-4642
SP  - 408
TI  - Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study
T2  - The Lancet Child and Adolescent Health
UR  - http://dx.doi.org/10.1016/S2352-4642(21)00026-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000653480600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/89410
VL  - 5
ER  - 

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