@article{Hayes:2023:10.1038/s41390-021-01749-3,
author = {Hayes, R and Hartnett, J and Semova, G and Murray, C and Murphy, K and Carroll, L and Plapp, H and Hession, L and O'Toole, J and McCollum, D and Roche, E and Jenkins, E and Mockler, D and Hurley, T and McGovern, M and Allen, J and Meehan, J and Plotz, FB and Strunk, T and de, Boode WP and Polin, R and Wynn, JL and Degtyareva, M and Kuester, H and Janota, J and Giannoni, E and Schlapbach, LJ and Keij, FM and Reiss, IKM and Bliss, J and Koenig, JM and Turner, MA and Gale, C and Molloy, EJ},
doi = {10.1038/s41390-021-01749-3},
journal = {Pediatric Research},
pages = {1141--1148},
title = {Neonatal sepsis definitions from randomised clinical trials},
url = {http://dx.doi.org/10.1038/s41390-021-01749-3},
volume = {93},
year = {2023}
}

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TY  - JOUR
AB  - Introduction:Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs).Method:A systematic search of the Embase and Cochrane databases was performed for RCTs which explicitly stated a definition for neonatal sepsis. Definitions were sub-divided into five primary criteria for infection (culture, laboratory findings, clinical signs, radiological evidence and risk factors) and stratified by qualifiers (early/late-onset and likelihood of sepsis).Results:Of 668 papers screened, 80 RCTs were included and 128 individual definitions identified. The single most common definition was neonatal sepsis defined by blood culture alone (n = 35), followed by culture and clinical signs (n = 29), and then laboratory tests/clinical signs (n = 25). Blood culture featured in 83 definitions, laboratory testing featured in 48 definitions while clinical signs and radiology featured in 80 and 8 definitions, respectively.Discussion:A diverse range of definitions of neonatal sepsis are used and based on microbiological culture, laboratory tests and clinical signs in contrast to adult and paediatric sepsis which use organ dysfunction. An international consensus-based definition of neonatal sepsis could allow meta-analysis and translate results to improve outcomes.
AU  - Hayes,R
AU  - Hartnett,J
AU  - Semova,G
AU  - Murray,C
AU  - Murphy,K
AU  - Carroll,L
AU  - Plapp,H
AU  - Hession,L
AU  - O'Toole,J
AU  - McCollum,D
AU  - Roche,E
AU  - Jenkins,E
AU  - Mockler,D
AU  - Hurley,T
AU  - McGovern,M
AU  - Allen,J
AU  - Meehan,J
AU  - Plotz,FB
AU  - Strunk,T
AU  - de,Boode WP
AU  - Polin,R
AU  - Wynn,JL
AU  - Degtyareva,M
AU  - Kuester,H
AU  - Janota,J
AU  - Giannoni,E
AU  - Schlapbach,LJ
AU  - Keij,FM
AU  - Reiss,IKM
AU  - Bliss,J
AU  - Koenig,JM
AU  - Turner,MA
AU  - Gale,C
AU  - Molloy,EJ
DO  - 10.1038/s41390-021-01749-3
EP  - 1148
PY  - 2023///
SN  - 0031-3998
SP  - 1141
TI  - Neonatal sepsis definitions from randomised clinical trials
T2  - Pediatric Research
UR  - http://dx.doi.org/10.1038/s41390-021-01749-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000715006100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/92618
VL  - 93
ER  - 

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