@article{Engjom:2022:10.1136/bmjmed-2022-000190,
author = {Engjom, HM and Ramakrishnan, R and Vousden, N and Bunch, K and Morris, E and Simpson, NAB and Gale, C and O'Brien, P and Quigley, M and Brocklehurst, P and Kurinczuk, JJ and Knight, M},
doi = {10.1136/bmjmed-2022-000190},
journal = {BMJ Medicine},
title = {Severity of maternal SARS-CoV-2 infection and perinatal outcomes of women admitted to hospital during the omicron variant dominant period using UK Obstetric Surveillance System data: prospective, national cohort study},
url = {http://dx.doi.org/10.1136/bmjmed-2022-000190},
volume = {1},
year = {2022}
}

Download

TY  - JOUR
AB  - OBJECTIVES: To describe the severity of maternal infection when the omicron SARS-CoV-2 variant (B.1.1.529) was dominant (15 December 2021 to 14 March 2022) and describe outcomes by symptoms and vaccination status. DESIGN: Prospective, national cohort study using the UK Obstetric Surveillance System. SETTING: 94 hospitals in the UK with a consultant led maternity unit. PARTICIPANTS: Pregnant women admitted to hospital for any cause with a positive SARS-CoV-2 test. MAIN OUTCOME MEASURES: Symptomatic or asymptomatic infection, vaccination status by doses before admission, and severity of maternal infection (moderate or severe infection according to modified World Health Organization's criteria). RESULTS: Of 3699 women who were admitted to hospital, 986 (26.7%, 95% confidence interval 25.3% to 28.1%) had symptoms; of these, 144 (14.6%, 12.5% to 17.0%) had a moderate to severe infection, 99 (10.4%, 8.6% to 12.5%) of 953 received respiratory support, and 30 (3.0%, 2.1% to 4.3%) were admitted to an intensive care unit. Covid-19 specific drug treatment was given to 13 (43.3%) of the 30 women in intensive care. Four women with symptoms died (0.4%, 0.1% to 1.1%). Vaccination status was known for 845 (85.6%) women with symptoms; 489 (58.9%) were unvaccinated and only 55 (6.5%) had three doses. Moderate to severe infection was reported for 93 (19.0%) of 489 unvaccinated women with symptoms, decreasing to three (5.5%) of 55 after three doses. Among the 30 women with symptoms who were admitted to intensive care, 23 (76.7%) were unvaccinated and none had received three doses. CONCLUSION: Most women with severe covid-19 disease were unvaccinated and vaccine coverage among pregnant women admitted to hospital with SARS-CoV-2 was low. Ongoing action to prioritise and advocate for vaccine uptake in pregnancy is essential. A better understanding of the persistent low use of drug treatments is an urgent priority. TRIAL REGISTRATION: ISRCTN 40092247.
AU  - Engjom,HM
AU  - Ramakrishnan,R
AU  - Vousden,N
AU  - Bunch,K
AU  - Morris,E
AU  - Simpson,NAB
AU  - Gale,C
AU  - O'Brien,P
AU  - Quigley,M
AU  - Brocklehurst,P
AU  - Kurinczuk,JJ
AU  - Knight,M
DO  - 10.1136/bmjmed-2022-000190
PY  - 2022///
SN  - 2754-0413
TI  - Severity of maternal SARS-CoV-2 infection and perinatal outcomes of women admitted to hospital during the omicron variant dominant period using UK Obstetric Surveillance System data: prospective, national cohort study
T2  - BMJ Medicine
UR  - http://dx.doi.org/10.1136/bmjmed-2022-000190
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36936599
UR  - http://hdl.handle.net/10044/1/104769
VL  - 1
ER  - 

Download