@article{Ali:2023:10.1038/s41390-023-02527-z,
author = {Ali, S and Mactier, H and Morelli, A and Hurd, M and Placzek, A and Knight, M and Ladhani, S and Draper, E and Sharkey, D and Doherty, C and Kurinczuk, J and Quigley, M and Gale, C},
doi = {10.1038/s41390-023-02527-z},
journal = {Pediatric Research},
pages = {1203--1208},
title = {Neonatal outcomes of maternal SARS-CoV-2 infection in the UK: a prospective cohort study using active surveillance},
url = {http://dx.doi.org/10.1038/s41390-023-02527-z},
volume = {94},
year = {2023}
}

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TY  - JOUR
AB  - Background:Newborns may be affected by maternal SARS-CoV-2 infection during pregnancy. We aimed to describe the epidemiology, clinical course and short-term outcomes of babies admitted to a neonatal unit (NNU) following birth to a mother with confirmed SARS-CoV-2 infection within 7 days of birth.Methods:This is a UK prospective cohort study; all NHS NNUs, 1 March 2020 to 31 August 2020. Cases were identified via British Paediatric Surveillance Unit with linkage to national obstetric surveillance data. Reporting clinicians completed data forms. Population data were extracted from the National Neonatal Research Database.Results:A total of 111 NNU admissions (1.98 per 1000 of all NNU admissions) involved 2456 days of neonatal care (median 13 [IQR 5, 34] care days per admission). A total of 74 (67%) babies were preterm. In all, 76 (68%) received respiratory support; 30 were mechanically ventilated. Four term babies received therapeutic hypothermia for hypoxic ischaemic encephalopathy. Twenty-eight mothers received intensive care, with four dying of COVID-19. Eleven (10%) babies were SARS-CoV-2 positive. A total of 105 (95%) babies were discharged home; none of the three deaths before discharge was attributed to SARS-CoV-2.Conclusion:Babies born to mothers with SARS-CoV-2 infection around the time of birth accounted for a low proportion of total NNU admissions over the first 6 months of the UK pandemic. Neonatal SARS-CoV-2 was uncommon.Study registration:ISRCTN60033461; protocol available at http://www.npeu.ox.ac.uk/pru-mnhc/research-themes/theme-4/covid-19.
AU  - Ali,S
AU  - Mactier,H
AU  - Morelli,A
AU  - Hurd,M
AU  - Placzek,A
AU  - Knight,M
AU  - Ladhani,S
AU  - Draper,E
AU  - Sharkey,D
AU  - Doherty,C
AU  - Kurinczuk,J
AU  - Quigley,M
AU  - Gale,C
DO  - 10.1038/s41390-023-02527-z
EP  - 1208
PY  - 2023///
SN  - 0031-3998
SP  - 1203
TI  - Neonatal outcomes of maternal SARS-CoV-2 infection in the UK: a prospective cohort study using active surveillance
T2  - Pediatric Research
UR  - http://dx.doi.org/10.1038/s41390-023-02527-z
UR  - http://hdl.handle.net/10044/1/102782
VL  - 94
ER  - 

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