@article{Vousden:2022:10.1136/bmjmed-2021-000053,
author = {Vousden, N and Ramakrishnan, R and Bunch, K and Morris, E and Simpson, NAB and Gale, C and O'Brien, P and Quigley, M and Brocklehurst, P and Kurinczuk, JJ and Knight, M},
doi = {10.1136/bmjmed-2021-000053},
journal = {BMJ Medicine},
title = {Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study},
url = {http://dx.doi.org/10.1136/bmjmed-2021-000053},
volume = {1},
year = {2022}
}

Download

TY  - JOUR
AB  - OBJECTIVE: To compare the severity of maternal infection and perinatal outcomes during periods in which wildtype, alpha variant, and delta variant of SARS-CoV-2 were dominant in the UK. DESIGN: Prospective cohort study. SETTING: 194 obstetric units across the UK, during the following periods: between 1 March and 30 November 2020 (wildtype dominance), between 1 December 2020 and 15 May 2021 (alpha variant dominance), and between 16 May and 31 October 2021 (delta variant dominance). PARTICIPANTS: 4436 pregnant women admitted to hospital with covid-19 related symptoms. MAIN OUTCOME MEASURES: Moderate to severe maternal SARS-CoV-2 infection (indicated by any of the following: oxygen saturation <95% on admission, need for oxygen treatment, evidence of pneumonia on imaging, admission to intensive care, or maternal death), and pregnancy and perinatal outcomes (including mode and gestation of birth, stillbirth, live birth, admission to neonatal intensive care, and neonatal death). RESULTS: 1387, 1613, and 1436 pregnant women were admitted to hospital with covid-19 related symptoms during the wildtype, alpha, and delta dominance periods, respectively; of these women, 340, 585, and 614 had moderate to severe infection, respectively. The proportion of pregnant women admitted with moderate to severe infection increased during the subsequent alpha and delta dominance periods, compared with the wildtype dominance period (wildtype 24.5% v alpha 36.2% (adjusted odds ratio 1.98, 95% confidence interval 1.66% to 2.37%); wildtype 24.5% v delta 42.8% (2.66, 2.21 to 3.20)). Compared with the wildtype dominance period, women admitted during the alpha dominance period were significantly more likely to have pneumonia, require respiratory support, and be admitted to intensive care; these three risks were even greater during the delta dominance period (wildtype v delta: pneumonia, adjusted odds ratio 2.52, 95% confidence interval 2.06 to 3.09; respiratory support, 1.90, 1.52 to 2.3
AU  - Vousden,N
AU  - Ramakrishnan,R
AU  - Bunch,K
AU  - Morris,E
AU  - Simpson,NAB
AU  - Gale,C
AU  - O'Brien,P
AU  - Quigley,M
AU  - Brocklehurst,P
AU  - Kurinczuk,JJ
AU  - Knight,M
DO  - 10.1136/bmjmed-2021-000053
PY  - 2022///
SN  - 2754-0413
TI  - Severity of maternal infection and perinatal outcomes during periods of SARS-CoV-2 wildtype, alpha, and delta variant dominance in the UK: prospective cohort study
T2  - BMJ Medicine
UR  - http://dx.doi.org/10.1136/bmjmed-2021-000053
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36936566
UR  - http://hdl.handle.net/10044/1/102998
VL  - 1
ER  - 

Download