@article{Gale:2014:10.3945/ajcn.113.080200,
author = {Gale, C and Thomas, EL and Jeffries, S and Durighel, G and Logan, KM and Parkinson, JRC and Uthaya, S and Santhakumaran, S and Bell, JD and Modi, N},
doi = {10.3945/ajcn.113.080200},
journal = {American Journal of Clinical Nutrition},
pages = {1034--1040},
title = {Adiposity and hepatic lipid in healthy full-term, breastfed, and formula-fed human infants: a prospective short-term longitudinal cohort study},
url = {http://dx.doi.org/10.3945/ajcn.113.080200},
volume = {99},
year = {2014}
}

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TY  - JOUR
AB  - Background: The effect of mode of infant feeding on adiposity deposition is not fully understood.Objective: The objective was to test the hypothesis that differences in total and regional adipose tissue content and intrahepatocellular lipid (IHCL) arise in early infancy between breast- and formula-fed infants and to describe longitudinal changes.Design: This prospective longitudinal cohort study was performed in 2 hospitals in the United Kingdom. Healthy, full-term, appropriate weight-for-gestational age infants were recruited; adipose tissue volume and distribution were directly quantified by using whole-body magnetic resonance imaging; IHCL was assessed by in vivo proton magnetic resonance spectroscopy. Measurements were performed after birth (median age: 13 d) and at 6–12 wk of age. Method of infant feeding was recorded prospectively by using maternally completed feeding diaries. Breastfed was defined as >80% of feeds consisting of breast milk at both points; formula-fed was defined as >80% of feeds consisting of formula milk at both points.Results: Longitudinal results were obtained from 70 infants (36 breastfed, 9 mixed-fed, and 25 formula-fed). No differences were found in total or regional adipose tissue or IHCL between breastfed and formula-fed infants. In pooled analyses including all feeding groups, IHCL and total adipose tissue approximately doubled between birth and 6–12 wk: IHCL after birth (median: 0.949; IQR: 0.521–1.711) and at 6–12 wk (1.828; 1.376–2.697; P < 0.001) and total adipose tissue after birth (0.749 L; 0.620–0.928 L) and at 6–12 wk (1.547 L; 1.332–1.790 L; P < 0.001). Increasing adiposity was characterized by greater relative increases in subcutaneous than in internal adipose tissue depots.Conclusions: No differences were detectable in adipose tissue or IHCL accretion between breastfed and formula-fed infants up to 2 mo. The substantial increase in IHCL seen over this period in bo
AU  - Gale,C
AU  - Thomas,EL
AU  - Jeffries,S
AU  - Durighel,G
AU  - Logan,KM
AU  - Parkinson,JRC
AU  - Uthaya,S
AU  - Santhakumaran,S
AU  - Bell,JD
AU  - Modi,N
DO  - 10.3945/ajcn.113.080200
EP  - 1040
PY  - 2014///
SN  - 0002-9165
SP  - 1034
TI  - Adiposity and hepatic lipid in healthy full-term, breastfed, and formula-fed human infants: a prospective short-term longitudinal cohort study
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.3945/ajcn.113.080200
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000334895700011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 99
ER  - 

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