@article{Logan:2016:10.1136/archdischild-2015-309750,
author = {Logan, K and Gale, C and Hyde, M and Santhakumaran, S and Modi, N},
doi = {10.1136/archdischild-2015-309750},
journal = {Archives of Disease in Childhood-Fetal and Neonatal Edition},
pages = {F65--F72},
title = {Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis},
url = {http://dx.doi.org/10.1136/archdischild-2015-309750},
volume = {102},
year = {2016}
}

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TY  - JOUR
AB  - Objective: Maternal glycaemia and anthropometry-derived newborn adiposity are stronglycorrelated. The children of mothers with diabetes are at greater risk of adverse metabolichealth, and increased adiposity is a plausible mediator. We undertook a systematic review andmeta-analysis to compare adiposity in infants of mothers with (IDM) and without diabetes(NIDM).Design: We identified observational studies reporting adiposity in IDM and NIDM. We searchedreferences, traced forward citations and contacted authors for additional data. We consideredall body composition techniques and compared fat mass, fat-free mass, body fat % and skinfoldthickness. We used random effects meta-analyses and performed subgroup analyses bymaternal diabetes type (type 1, type 2, gestational) and infant sex. We examined the influenceof pre-pregnancy BMI and conducted sensitivity analyses.Results: We included data from 35 papers and over 24,000 infants. IDM have greater fatmass than NIDM (mean difference [95% CI]); 83g [49, 117]. Fat mass is greater in infants ofmothers with gestational diabetes; 62g [29, 94] and type 1 diabetes; 268g [139, 397].Insufficient studies reported data for type 2 diabetes separately. Compared with NIDM, fatmass was greater in IDM boys; 87g [30, 145], but not significantly different in IDM girls; 42g [-33, 116]. There was no attenuation after adjustment for maternal BMI.Conclusions: IDM have significantly greater adiposity in comparison to NIDM. These findingsare justification for studies to determine whether measures to reduce infant adiposity willimprove later health.
AU  - Logan,K
AU  - Gale,C
AU  - Hyde,M
AU  - Santhakumaran,S
AU  - Modi,N
DO  - 10.1136/archdischild-2015-309750
EP  - 72
PY  - 2016///
SN  - 1468-2052
SP  - 65
TI  - Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis
T2  - Archives of Disease in Childhood-Fetal and Neonatal Edition
UR  - http://dx.doi.org/10.1136/archdischild-2015-309750
UR  - http://hdl.handle.net/10044/1/31559
VL  - 102
ER  - 

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