@article{Duffy:2016:10.1016/j.preghy.2016.04.008,
author = {Duffy, JMN and van, t'Hooft J and Gale, CRK and Brown, M and Grobman, W and Fitzpatrick, R and Ananth, Karumanthi S and Lucas, N and Magee, L and Mol, B and Stark, M and Thangaratinam, S and Wilson, M and von, Dadelszen P and Williamson, P and Khan, KS and Ziebland, S and McManus, RJ and On, behalf of the International Collaboration to Harmonise Outcomes for Pre-eclampsia iHOPE},
doi = {10.1016/j.preghy.2016.04.008},
journal = {Pregnancy Hypertension},
pages = {274--278},
title = {A protocol for developing, disseminating, and implementing a core outcome set for pre-eclampsia},
url = {http://dx.doi.org/10.1016/j.preghy.2016.04.008},
volume = {6},
year = {2016}
}

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TY  - JOUR
AB  - BackgroundPre-eclampsia is a serious complication of pregnancy and contributes to maternaland offspring mortality and morbidity. Randomised controlled trials evaluatingtherapeutic interventions for pre-eclampsia have reported many different outcomesand outcome measures. Such variation contributes to an inability to compare,contrast, and combine individual studies, limiting the usefulness of research to informclinical practice. The development and use of a core outcome set would help toaddress these issues ensuring outcomes important to all stakeholders, includingpatients, will be collected and reported in a standardised fashion.MethodsAn international steering group including healthcare professionals, researchers, andpatients, has been formed to guide the development of this core outcome set.Potential outcomes will be identified through a comprehensive literature review andsemi-structured interviews with patients. Potential core outcomes will be entered intoan international, multi-perspective online Delphi survey. All key stakeholders,including healthcare professionals, researchers, and patients will be invited toparticipate. The modified Delphi method encourages whole and stakeholder groupconvergence towards consensus ‘core’ outcomes. Once core outcomes have beenagreed upon it is important to determine how they should be measured. The truth,discrimination, and feasibility assessment framework will assess the quality ofpotential outcome measures. High quality outcome measures will be associated withcore outcomes. Mechanisms exist to disseminate and implement the resulting coreoutcome set within an international context. DiscussionEmbedding the core outcome set within future clinical trials, systematic reviews, andclinical practice guidelines could make a profound contribution to advancing theusefulness of research to inform clinical practice, enhance patient care, and improvematernal and offspring outcomes. The infrastructure created by developing a core
AU  - Duffy,JMN
AU  - van,t'Hooft J
AU  - Gale,CRK
AU  - Brown,M
AU  - Grobman,W
AU  - Fitzpatrick,R
AU  - Ananth,Karumanthi S
AU  - Lucas,N
AU  - Magee,L
AU  - Mol,B
AU  - Stark,M
AU  - Thangaratinam,S
AU  - Wilson,M
AU  - von,Dadelszen P
AU  - Williamson,P
AU  - Khan,KS
AU  - Ziebland,S
AU  - McManus,RJ
AU  - On,behalf of the International Collaboration to Harmonise Outcomes for Pre-eclampsia iHOPE
DO  - 10.1016/j.preghy.2016.04.008
EP  - 278
PY  - 2016///
SN  - 2210-7797
SP  - 274
TI  - A protocol for developing, disseminating, and implementing a core outcome set for pre-eclampsia
T2  - Pregnancy Hypertension
UR  - http://dx.doi.org/10.1016/j.preghy.2016.04.008
UR  - http://hdl.handle.net/10044/1/32065
VL  - 6
ER  - 

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