@article{Mann:2016:10.1002/bdra.23507,
author = {Mann, JP and Statnikov, E and Modi, N and Johnson, N and Springett, A and Morris, JK},
doi = {10.1002/bdra.23507},
journal = {Birth Defects Research Part A-Clinical and Molecular Teratology},
pages = {468--474},
title = {Management and outcomes of neonates with down syndrome admitted to neonatal units},
url = {http://dx.doi.org/10.1002/bdra.23507},
volume = {106},
year = {2016}
}

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TY  - JOUR
AB  - BackgroundStudies have reported that advanced maternal age is a risk factor for congenital heart disease (CHD), but none of these have been performed in the United Kingdom. Currently, women in the United Kingdom are not referred for specialist fetal echocardiography based on maternal age alone. The aim of this study is to examine the association between maternal age at delivery and CHD prevalence in the North of England.MethodsSingleton cases of CHD notified to the Northern Congenital Abnormality Survey and born between January 1, 1998, to December 31, 2013, were included. Cases with chromosomal anomalies were excluded. The relative risk (RR) of CHD according to maternal age at delivery was estimated using Poisson regression.ResultsThere were 4024 singleton cases of nonchromosomal CHD, giving a prevalence of 8.1 (95% confidence interval [CI], 7.8–8.3) per 1000 live and stillbirths. There was no association between maternal age at delivery and CHD prevalence (p = 0.97), with no evidence of an increased risk of CHD in mothers aged ≥35 compared to aged 25 to 29 (RR = 0.99; 95% CI, 0.89–1.09). There were no significant associations between maternal age at delivery and severity III CHD (p = 0.84), severity II CHD (p = 0.74), or severity I CHD (p = 0.66), although there was a slight increased risk of severity I CHD in mothers aged ≥35 (RR = 1.27; 95% CI, 0.83–1.95).ConclusionWe found little evidence that advanced maternal age is a risk factor for CHD. There is no evidence that women in the United Kingdom should be referred for specialist prenatal cardiac screening based on their age.
AU  - Mann,JP
AU  - Statnikov,E
AU  - Modi,N
AU  - Johnson,N
AU  - Springett,A
AU  - Morris,JK
DO  - 10.1002/bdra.23507
EP  - 474
PY  - 2016///
SN  - 1542-9768
SP  - 468
TI  - Management and outcomes of neonates with down syndrome admitted to neonatal units
T2  - Birth Defects Research Part A-Clinical and Molecular Teratology
UR  - http://dx.doi.org/10.1002/bdra.23507
VL  - 106
ER  - 

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