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  • Journal article
    Battersby C, Modi N, 2019,

    Challenges in advancing necrotizing enterocolitis research

    , Clinics in Perinatology, Vol: 46, Pages: 19-27, ISSN: 0095-5108

    Progressing necrotizing enterocolitis research is difficult because the disease is variable in presentation, there are difficulties in making a precise diagnosis, a reliable agreed case-definition is currently lacking, and there is a paucity of preclinical research to identify etiologic targets. The major challenges of the cost of clinical trials and need for long-term outcome ascertainment could be eased through incorporation of novel randomization approaches and data collection into routine care, and collaboration between public-sector and industry funders.
  • Conference paper
    Jenkins HJ, Hyde MJ, Modi N, Marchesi Jet al., 2019,

    An Investigation of 16S rRNA Gene Analysis Platforms for Processing Samples Acquired from Preterm Neonates.

    , 66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Publisher: SAGE PUBLICATIONS INC, Pages: 121A-121A, ISSN: 1933-7191
  • Conference paper
    Mitchell E, Dorling J, Montgomery A, Ogollah R, McGuire W, Oddie S, Gale C, Johnson M, Mistry H, Walker K, Pallotti P, Kenyon C, Ojha Set al., 2019,

    Fluids exclusively enteral from day 1: a randomised controlled trial of full milk feeds versus intravenous nutrition with gradual feeding for preterm infants (30-33 weeks' gestational age) (The FEED1 Trial)

    , Publisher: WILEY, Pages: 126-126, ISSN: 1470-0328
  • Journal article
    Seaton SE, Barker L, Draper ES, Abrams KR, Modi N, Manktelow BN, UK Neonatal Collaborativeet al., 2019,

    Estimating neonatal length of stay for babies born very preterm

    , Archives of Disease in Childhood. Fetal and Neonatal Edition, Vol: 104, Pages: F182-F186, ISSN: 1359-2998

    OBJECTIVE: To predict length of stay in neonatal care for all admissions of very preterm singleton babies. SETTING: All neonatal units in England. PATIENTS: Singleton babies born at 24-31 weeks gestational age from 2011 to 2014. Data were extracted from the National Neonatal Research Database. METHODS: Competing risks methods were used to investigate the competing outcomes of death in neonatal care or discharge from the neonatal unit. The occurrence of one event prevents the other from occurring. This approach can be used to estimate the percentage of babies alive, or who have been discharged, over time. RESULTS: A total of 20 571 very preterm babies were included. In the competing risks model, gestational age was adjusted for as a time-varying covariate, allowing the difference between weeks of gestational age to vary over time. The predicted percentage of death or discharge from the neonatal unit were estimated and presented graphically by week of gestational age. From these percentages, estimates of length of stay are provided as the number of days following birth and corrected gestational age at discharge. CONCLUSIONS: These results can be used in the counselling of parents about length of stay and the risk of mortality.
  • Journal article
    Molloy E, Mader S, Modi N, Gale Cet al., 2019,

    Parent, Child and Public Involvement in Child Health Research: Core value not just an optional extra

    , Pediatric Research, Vol: 85, Pages: 2-3, ISSN: 0031-3998
  • Journal article
    Modi N, Ashby D, Battersby C, Brocklehurst P, Chivers Z, Costeloe K, Draper E, Foster V, Kemp J, Majeed A, Murray J, Petrou S, Rogers K, Santhakumaran S, Saxena S, Statnikov Y, Wong H, Young Aet al.,

    Using routinely recorded clinical data for research: the Medicines for Neonates research programme

    , Programme Grants for Applied Research, ISSN: 2050-4322

    Background: Clinical data offer potential to advance patient care. Neonatal specialised care is a high cost NHS service received by approximately 80,000 newborn infants each year. Objectives: To 1) develop the use of routinely recorded operational clinical data from Electronic Patient Records (EPR), secure national coverage, evaluate and improve the quality of clinical data, and develop their use as a national resource to improve neonatal healthcare and outcomes; test the hypotheses that 2) clinical and research data are of comparable quality; 3) routine NHS clinical assessment at age two-years reliably identifies children with neurodevelopmental impairment; and 4) trial-based economic evaluations of neonatal interventions can be reliably conducted using clinical data; 5) test methods to link NHS datasets; 6) evaluate parent views of personal data in research Design: Six interrelated work-streams; quarterly extractions of predefined data from neonatal EPR; approvals from the National Research Ethics Service, Health Research Authority Confidentiality Advisory Group, Caldicott Guardians and lead neonatal clinicians of participating NHS Trusts Setting: NHS neonatal unitsParticipants: Neonatal clinical teams; parents of babies admitted to NHS neonatal unitsInterventions: In work-stream 3 we employed the Bayley-III scales to evaluate neurodevelopmental status and the Quantitative Checklist of Autism in Toddlers (Q-CHAT) to evaluate social-communication skills. In work-stream 6 we recruited parents with previous experience of a child in neonatal care to assist in the design of a questionnaire directed at the parents of infants admitted to neonatal units. Data sources: Data extracted from the EPR of admissions to NHS neonatal units Main outcomes and results: We created a National Neonatal Research Database (NNRD) containing a defined extract from real-time, point-of-care, clinician-entered EPR from all NHS neonatal units in England, Wales and Scotland (n=200), establish
  • Journal article
    Neu J, Modi N, Caplan M, 2018,

    Necrotizing enterocolitis comes in different forms: Historical perspectives and defining the disease

    , SEMINARS IN FETAL & NEONATAL MEDICINE, Vol: 23, Pages: 370-373, ISSN: 1744-165X
  • Journal article
    Dos Santos F, Drymiotou S, Antequera A, Mol BW, Gale C, Devane D, Van't Hooft J, Johnson MJ, Hogg M, Thangaratinam Set al., 2018,

    Development of a core outcome set for trials on induction of labour (COSIOL): an international multi-stakeholder Delphi study

    , BJOG: An International Journal of Obstetrics and Gynaecology, Vol: 125, Pages: 1673-1680, ISSN: 1470-0328

    OBJECTIVE: To develop a set of core outcomes to be minimally reported in trials on induction of labour. DESIGN: Two-round Delphi survey and consensus meeting. POPULATION: Four Stakeholder groups: midwives, obstetricians, neonatologists, and women's representatives. METHODS: Protocol registered with COMET (registration number: 695). Stakeholders rated reported outcomes for importance (1-limited to 9-critical). The median rating of each outcome was calculated. The consensus criteria to include outcomes were: ≥ 70% participants rated outcomes as critical and <15% rated outcomes as limited importance. Outcomes that did not achieve consensus were taken to round two, and if still no consensus, to the final consensus meeting. MAIN OUTCOME MEASURES: Outcomes in trials of induction of labour. RESULTS: Of the 159 invited participants, 54% (86/159) completed the first round, and 83% completed the second round (71/86). The core outcome set included 28 core outcomes in four domains: Short-term maternal outcomes (n=18) - cardio-respiratory arrest, damage to internal organs, death, haemorrhage, hysterectomy, infection, intensive care admission, length of hospital stay, mode of delivery, need for more than one induction agent, oxytocin augmentation, postnatal depression, pulmonary embolus, satisfaction with care, stroke, time from induction to delivery, uterine hyperstimulation, uterine scar dehiscence/rupture; Short-term offspring outcomes (n=8) - admission to the neonatal unit, birth trauma, death, hypoxic ischaemic encephalopathy/need for therapeutic hypothermia, meconium aspiration syndrome, need for respiratory support, infection, seizures; Long-term maternal outcomes (n=1) - operative pelvic floor repair; Long-term offspring outcomes (n=1) - disability including neurodevelopmental delay. CONCLUSION: Trials on induction of labour should include this core outcome set to standardise reporting. This article is protected by copyright. All rights reserved.
  • Journal article
    Costeloe K, Turner MA, Padula MA, Shah PS, Modi N, Soll R, Haumont D, Kusuda S, Goepel W, Chang YS, Smith PB, Lui K, Davis JM, Hudson LDet al., 2018,

    Sharing Data to Accelerate Medicine Development and Improve Neonatal Care: Data Standards and Harmonized Definitions

    , JOURNAL OF PEDIATRICS, Vol: 203, Pages: 437-+, ISSN: 0022-3476
  • Journal article
    Shah PS, Kusuda S, Hakansson S, Reichman B, Lui K, Lehtonen L, Modi N, Vento M, Adams M, Rusconi F, Norman M, Darlow BA, Lodha A, Yang J, Bassler D, Helenius KK, Isayama T, Lee SKet al., 2018,

    Neonatal Outcomes of Very Preterm or Very Low Birth Weight Triplets

    , PEDIATRICS, Vol: 142, ISSN: 0031-4005

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

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