@article{Duffy:2017:10.1002/ijgo.12298,
author = {Duffy, JMN and Hirsch, M and Gale, CRK and Pealing, L and Kawsar, A and Showell, M and Williamson, PR and Khan, KS and Zeibland, S and McManus, RJ},
doi = {10.1002/ijgo.12298},
journal = {International Journal of Gynecology and Obstetrics},
pages = {262--267},
title = {A systematic review of primary outcomes and outcome measure reporting in randomized trials evaluating treatments for pre-eclampsia},
url = {http://dx.doi.org/10.1002/ijgo.12298},
volume = {139},
year = {2017}
}

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TY  - JOUR
AB  - BackgroundAn evaluation of outcome reporting is required to develop a core outcome set.ObjectivesTo assess primary outcomes and outcome measure reporting in pre-eclampsia trials.Search strategyFive online databases were searched from inception to January 2016 using terms including “preeclampsia” and “randomized controlled trial”.Selection criteriaRandomized controlled trials evaluating treatments for pre-eclampsia published in any language were included.Data collection and analysisPrimary outcomes and data on outcome measure reporting were systematically extracted and categorized.Main resultsOverall, 79 randomized trials including data from 31 615 women were included. Of those, 38 (48%) reported 35 different primary outcomes; 28 were maternal outcomes and seven were fetal/neonatal outcomes. Three randomized trials reported composite outcomes, incorporating between six and nine outcome components. The method of definition or measurement was infrequently or poorly reported. Even when outcomes were consistent across trials, different methods of definition or measurement were frequently described.ConclusionsIn randomized trials evaluating interventions for pre-eclampsia, critical information related to the primary outcome, including definition and measurement, is regularly omitted. Developing a core outcome set for pre-eclampsia trials would help to inform primary outcome selection and outcome measure reporting.
AU  - Duffy,JMN
AU  - Hirsch,M
AU  - Gale,CRK
AU  - Pealing,L
AU  - Kawsar,A
AU  - Showell,M
AU  - Williamson,PR
AU  - Khan,KS
AU  - Zeibland,S
AU  - McManus,RJ
DO  - 10.1002/ijgo.12298
EP  - 267
PY  - 2017///
SN  - 0020-7292
SP  - 262
TI  - A systematic review of primary outcomes and outcome measure reporting in randomized trials evaluating treatments for pre-eclampsia
T2  - International Journal of Gynecology and Obstetrics
UR  - http://dx.doi.org/10.1002/ijgo.12298
UR  - http://hdl.handle.net/10044/1/50425
VL  - 139
ER  - 

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