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@article{Sherrard-Smith:2018:10.7554/eLife.35213,
author = {Sherrard-Smith, E and Sala, KA and Betancourt, M and Upton, LM and Angrisano, F and Morin, MJ and Ghani, AC and Churcher, TS and Blagborough, AM},
doi = {10.7554/eLife.35213},
journal = {eLife},
title = {Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density},
url = {http://dx.doi.org/10.7554/eLife.35213},
volume = {7},
year = {2018}
}
TY - JOUR
AB - Anti-malarial pre-erythrocytic vaccines (PEV) target transmission by inhibiting human infection but are currently partially protective. It has been posited, but never demonstrated, that co-administering transmission-blocking vaccines (TBV) would enhance malaria control. We hypothesized a mechanism that TBV could reduce parasite density in the mosquito salivary glands, thereby enhancing PEV efficacy. This was tested using a multigenerational population assay, passaging Plasmodium berghei to Anopheles stephensi mosquitoes. A combined efficacy of 90.8% (86.7–94.2%) was observed in the PEV +TBV antibody group, higher than the estimated efficacy of 83.3% (95% CrI 79.1–87.0%) if the two antibodies acted independently. Higher PEV efficacy at lower mosquito parasite loads was observed, comprising the first direct evidence that co-administering anti-sporozoite and anti-transmission interventions act synergistically, enhancing PEV efficacy across a range of TBV doses and transmission intensities. Combining partially effective vaccines of differing anti-parasitic classes is a pragmatic, powerful way to accelerate malaria elimination efforts.
AU - Sherrard-Smith,E
AU - Sala,KA
AU - Betancourt,M
AU - Upton,LM
AU - Angrisano,F
AU - Morin,MJ
AU - Ghani,AC
AU - Churcher,TS
AU - Blagborough,AM
DO - 10.7554/eLife.35213
PY - 2018///
SN - 2050-084X
TI - Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density
T2 - eLife
UR - http://dx.doi.org/10.7554/eLife.35213
UR - http://hdl.handle.net/10044/1/60240
VL - 7
ER -
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