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@article{Slater:2019:10.1038/s41467-019-09441-1,
author = {Slater, H and Ross, A and Felger, I and Hofmann, N and Robinson, L and Cook, J and Goncalves and Bjorkman and Ouedraogo and Morris and Msellem and Koepfli and Mueller and Tadesse and Gadisa and Das and Domingo and Kapulu and Midega, J and Owusu-Agyei and Nabet and Piarroux and Doumbo and Doumbo and Koram and Lucchi and Udhayakumar and Mosha and Tiono and Chandramohan and Gosling and Mwingira and Sauerwein and Riley and White and Nosten and Imwong and Bousema and Drakeley and Okell, L},
doi = {10.1038/s41467-019-09441-1},
journal = {Nature Communications},
title = {The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density},
url = {http://dx.doi.org/10.1038/s41467-019-09441-1},
volume = {10},
year = {2019}
}

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TY  - JOUR
AB  - Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
AU  - Slater,H
AU  - Ross,A
AU  - Felger,I
AU  - Hofmann,N
AU  - Robinson,L
AU  - Cook,J
AU  - Goncalves
AU  - Bjorkman
AU  - Ouedraogo
AU  - Morris
AU  - Msellem
AU  - Koepfli
AU  - Mueller
AU  - Tadesse
AU  - Gadisa
AU  - Das
AU  - Domingo
AU  - Kapulu
AU  - Midega,J
AU  - Owusu-Agyei
AU  - Nabet
AU  - Piarroux
AU  - Doumbo
AU  - Doumbo
AU  - Koram
AU  - Lucchi
AU  - Udhayakumar
AU  - Mosha
AU  - Tiono
AU  - Chandramohan
AU  - Gosling
AU  - Mwingira
AU  - Sauerwein
AU  - Riley
AU  - White
AU  - Nosten
AU  - Imwong
AU  - Bousema
AU  - Drakeley
AU  - Okell,L
DO  - 10.1038/s41467-019-09441-1
PY  - 2019///
SN  - 2041-1723
TI  - The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-09441-1
UR  - http://hdl.handle.net/10044/1/68730
VL  - 10
ER  -

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