BibTex format
@article{Mousa:2020:10.1371/journal.pmed.1003359,
author = {Mousa, A and Al-Taiar, A and Anstey, NM and Badaut, C and Barber, BE and Bassat, Q and Challenger, J and Cunnington, AJ and Datta, D and Drakeley, C and Ghani, AC and Gordeuk, VR and Grigg, MJ and Hugo, P and John, CC and Mayor, A and Migot-Nabias, F and Opoka, RO and Pasvol, G and Rees, C and Reyburn, H and Riley, EM and Shah, BN and Sitoe, A and Sutherland, CJ and Thuma, PE and Unger, SA and Viwami, F and Walther, M and Whitty, CJM and William, T and Okell, LC},
doi = {10.1371/journal.pmed.1003359},
journal = {PLoS Medicine},
pages = {1--28},
title = {The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: a systematic review and a pooled multicentre individual-patient meta-analysis},
url = {http://dx.doi.org/10.1371/journal.pmed.1003359},
volume = {17},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background: Delay in receiving treatment for uncomplicated malaria is often reported to increase the risk of developing severe malaria, but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as “test-and-treat” policies administered by community health workers. We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with severe malaria.Methods and Findings: A search using Ovid MEDLINE and Embase was initially conducted to identify studies on severe P. falciparum malaria which included information on treatment delay, such as fever duration 12(inceptions to 22nd September 2017). Studies identified included five case-control and eight other observational clinical studies of severe and uncomplicated malaria cases. Risk of bias was assessed using the Newcastle–Ottawa scale and all studies were ranked as “Good”, scoring ≥7/10. Individual-patient data were pooled from thirteen studies of 3,989(94.1% aged <15 years)severe malaria patients and 5,780(79.6% aged <15 years)uncomplicated malaria cases in Benin, Malaysia, Mozambique, Tanzania, The Gambia, Uganda, Yemen and Zambia. Definitions of severe malaria were standardised across studies to compare treatment delay in patients with uncomplicated malaria and different severe malaria phenotypes using age-adjusted mixed-effects regression. The odds of any severe malaria phenotype were significantly higher in children with longer delays between initial symptoms and arrival at the health facility (OR=1.33, 95%CI:1.07-1.64 for a delay of >24 hours vs. ≤24 hours;p=0.009). Reported illness duration was a strong predictor of presenting with severe malarial anaemia (SMA) in children
AU - Mousa,A
AU - Al-Taiar,A
AU - Anstey,NM
AU - Badaut,C
AU - Barber,BE
AU - Bassat,Q
AU - Challenger,J
AU - Cunnington,AJ
AU - Datta,D
AU - Drakeley,C
AU - Ghani,AC
AU - Gordeuk,VR
AU - Grigg,MJ
AU - Hugo,P
AU - John,CC
AU - Mayor,A
AU - Migot-Nabias,F
AU - Opoka,RO
AU - Pasvol,G
AU - Rees,C
AU - Reyburn,H
AU - Riley,EM
AU - Shah,BN
AU - Sitoe,A
AU - Sutherland,CJ
AU - Thuma,PE
AU - Unger,SA
AU - Viwami,F
AU - Walther,M
AU - Whitty,CJM
AU - William,T
AU - Okell,LC
DO - 10.1371/journal.pmed.1003359
EP - 28
PY - 2020///
SN - 1549-1277
SP - 1
TI - The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: a systematic review and a pooled multicentre individual-patient meta-analysis
T2 - PLoS Medicine
UR - http://dx.doi.org/10.1371/journal.pmed.1003359
UR - https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003359
UR - http://hdl.handle.net/10044/1/82725
VL - 17
ER -
