@article{White:2014:10.7554/eLife.04692,
author = {White, MT and Karl, S and Battle, K and Hay, SI and Mueller, I and Ghani, AC},
doi = {10.7554/eLife.04692},
journal = {eLife},
title = {Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission},
url = {http://dx.doi.org/10.7554/eLife.04692},
volume = {3},
year = {2014}
}

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TY  - JOUR
AB  - Plasmodium vivax relapse infections occur following activation of latent liver-stagesparasites (hypnozoites) causing new blood-stage infections weeks to months after the initialinfection. We develop a within-host mathematical model of liver-stage hypnozoites, and validateit against data from tropical strains of P. vivax. The within-host model is embedded in a P. vivaxtransmission model to demonstrate the build-up of the hypnozoite reservoir following newinfections and its depletion through hypnozoite activation and death. The hypnozoite reservoiris predicted to be over-dispersed with many individuals having few or no hypnozoites, and somehaving intensely infected livers. Individuals with more hypnozoites are predicted to experiencemore relapses and contribute more to onwards P. vivax transmission. Incorporating hypnozoitekilling drugs such as primaquine into first-line treatment regimens is predicted to cause substantialreductions in P. vivax transmission as individuals with the most hypnozoites are more likely torelapse and be targeted for treatment.
AU  - White,MT
AU  - Karl,S
AU  - Battle,K
AU  - Hay,SI
AU  - Mueller,I
AU  - Ghani,AC
DO  - 10.7554/eLife.04692
PY  - 2014///
SN  - 2050-084X
TI  - Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.04692
UR  - http://hdl.handle.net/10044/1/26834
VL  - 3
ER  - 

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