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@article{Puttaraksa:2019:10.1152/jn.00407.2019,
author = {Puttaraksa, G and Muceli, S and Alvaro, Gallego J and Holobar, A and Charles, SK and Pons, JL and Farina, D},
doi = {10.1152/jn.00407.2019},
journal = {Journal of Neurophysiology},
pages = {2043--2053},
title = {Voluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients},
url = {http://dx.doi.org/10.1152/jn.00407.2019},
volume = {122},
year = {2019}
}
TY - JOUR
AB - Pathological tremor is an oscillation of body parts at 3–10 Hz, determined by the output of spinal motor neurons (MNs), which receive synaptic inputs from supraspinal centers and muscle afferents. The behavior of spinal MNs during tremor is not well understood, especially in relation to the activation of the multiple muscles involved. Recent studies on patients with essential tremor have shown that antagonist MN pools receive shared input at the tremor frequency. In this study, we investigated the synaptic inputs related to tremor and voluntary movement, and their coordination across antagonist muscles. We analyzed the spike trains of motor units (MUs) identified from high-density surface electromyography from the forearm extensor and flexor muscles in 15 patients with essential tremor during postural tremor. The shared synaptic input was quantified by coherence and phase difference analysis of the spike trains. All pairs of spike trains in each muscle showed coherence peaks at the voluntary drive frequency (1–3 Hz, 0.2 ± 0.2, mean ± SD) and tremor frequency (3–10 Hz, 0.6 ± 0.3) and were synchronized with small phase differences (3.3 ± 25.2° and 3.9 ± 22.0° for the voluntary drive and tremor frequencies, respectively). The coherence between MN spike trains of antagonist muscle groups at the tremor frequency was significantly smaller than intramuscular coherence. We predominantly observed in-phase activation of MUs between agonist/antagonist muscles at the voluntary frequency band (0.6 ± 48.8°) and out-of-phase activation at the tremor frequency band (126.9 ± 75.6°). Thus MNs innervating agonist/antagonist muscles concurrently receive synaptic inputs with different phase shifts in the voluntary and tremor frequency bands.
AU - Puttaraksa,G
AU - Muceli,S
AU - Alvaro,Gallego J
AU - Holobar,A
AU - Charles,SK
AU - Pons,JL
AU - Farina,D
DO - 10.1152/jn.00407.2019
EP - 2053
PY - 2019///
SN - 0022-3077
SP - 2043
TI - Voluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients
T2 - Journal of Neurophysiology
UR - http://dx.doi.org/10.1152/jn.00407.2019
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000498170200019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://journals.physiology.org/doi/full/10.1152/jn.00407.2019
UR - http://hdl.handle.net/10044/1/82395
VL - 122
ER -