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@article{Luft:2021:10.7554/eLife.71312.sa2,
author = {Luft, M and Klepetko, J and Muceli, S and Ibanez, J and Tereshenko, V and Festin, C and Laengle, G and Politikou, O and Maierhofer, U and Farina, D and Aszmann, OC and Bergmeister, KD},
doi = {10.7554/eLife.71312.sa2},
journal = {eLife},
pages = {1--16},
title = {Proof of concept for multiple nerve transfers to a single target muscle},
url = {http://dx.doi.org/10.7554/eLife.71312.sa2},
volume = {10},
year = {2021}
}
TY - JOUR
AB - Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas,phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferredto one target muscle. However, the transfer of multiple nerves onto a single target muscle mayincrease the number of muscle signals for myoelectric prosthetic control and facilitate the treatmentof multiple neuromas. Currently, no experimental models are available. This study describes anovel experimental model to investigate the neurophysiological effects of peripheral double nervetransfers to a common target muscle. In 62 male Sprague-Dawleyrats, the ulnar nerve of the antebrachiumalone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervatethe long head of the biceps brachii. Before neurotization, the motor branch to the biceps’long head was transected at the motor entry point. Twelve weeks after surgery, muscle responseto neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed toassess reinnervation. These analyses indicated that all nerves successfully reinnervated the targetmuscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observationssuggest a minimal burden for the animal with no signs of functional deficit in daily activities orauto-mutilationin both procedures. Furthermore, standard neurophysiological analyses for nerveand muscle regeneration were applicable. This newly developed nerve transfer model allows for thereliable and standardized investigation of neural and functional changes following the transfer ofmultiple donor nerves to one target muscle.
AU - Luft,M
AU - Klepetko,J
AU - Muceli,S
AU - Ibanez,J
AU - Tereshenko,V
AU - Festin,C
AU - Laengle,G
AU - Politikou,O
AU - Maierhofer,U
AU - Farina,D
AU - Aszmann,OC
AU - Bergmeister,KD
DO - 10.7554/eLife.71312.sa2
EP - 16
PY - 2021///
SN - 2050-084X
SP - 1
TI - Proof of concept for multiple nerve transfers to a single target muscle
T2 - eLife
UR - http://dx.doi.org/10.7554/eLife.71312.sa2
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000711418600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://elifesciences.org/articles/71312#sa2
UR - http://hdl.handle.net/10044/1/93599
VL - 10
ER -