In this section
@article{Badura:2016:10.1038/srep36131,
author = {Badura, A and Clopath, C and Schonewille, M and De, Zeeuw CI},
doi = {10.1038/srep36131},
journal = {Scientific Reports},
title = {Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments},
url = {http://dx.doi.org/10.1038/srep36131},
volume = {6},
year = {2016}
}
TY - JOUR
AB - Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebellar cortex and vestibular nuclei, reproduces behavioral data and accounts for the changes in neural activity during learning in wild type mice. Here, we used our model to predict Purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry. We tested these predictions by obtaining electrophysiological data depicting changes in neuronal spiking. We show that our data is largely consistent with the model predictions for simple spike modulation of Purkinje cells and concomitant behavioral learning in four of the mutants. In addition, our model accurately predicts a shift in simple spike activity in a mutant mouse with a brainstem specific mutation. This combination of electrophysiological and computational techniques opens a possibility of predicting behavioral impairments from neural activity.
AU - Badura,A
AU - Clopath,C
AU - Schonewille,M
AU - De,Zeeuw CI
DO - 10.1038/srep36131
PY - 2016///
SN - 2045-2322
TI - Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/srep36131
UR - http://hdl.handle.net/10044/1/41299
VL - 6
ER -