First example of an X-ray crystal structure showing the interaction between a metal complex and quadruplex DNA
Published by our group jointly with Prof. Neidle's group (School of Pharmacy) in J. Med. Chem.
Molecular Basis of Structure-Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes, Nancy H. Campbell, Nurul H. Abd Karim, Gary N. Parkinson, Mekala Gunaratnam,Vanessa Petrucci, Alan K. Todd, Ramon Vilar and Stephen Neidle, J. Med. Chem. 2012, Vol:55, Pages:209-222. DOI: dx.doi.org/10.1021/jm201140v
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