The use of soluble, non-crosslinked, Ge-functionalised, polystyrene as a support for the synthesis of a 4-aryl-2-anilinopyrimidine is described
Ratnasothy Srikaran, Christos A. Kontorgiorgis, Sarah A. Warren, Federica Pisaneschi, and Alan C. Spivey 'Synthesis of a 4-aryl-2-anilinopyrimidine using a germanium-functionalised non cross-linked polystyrene (NCPS) support' Synlett, 2013, ASAP.
The use of a germanium-functionalised non cross-linked polystyrene (NCPS) support to aid the preparation of 2-anilino-4-arylpyrimidine 3 is described. This compound is a key intermediate en route to various IKK-2 and JNK inhibitors.
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Professor Alan C Spivey
Department of Chemistry
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Email: a.c.spivey@imperial.ac.uk
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