Laurence Carroll and Helen Evans' mini-review on pre-targeted strategies for Positron Emission Tomography (PET) is published.
Laurence Carroll, Helen L. Evans, Eric O. Aboagye and Alan C. Spivey, ‘Bioorthogonal chemistry for pre-targeted molecular imaging – progress and prospects ‘, Org. Biomol. Chem., 2013, 11, 5772-5781 DOI: 10.1039/C3OB40897C
The aim of this perspective is to critically review the three most prominent bioorthogonal reactions that are used presently, on both a purely chemical level and in the context of biological systems. This includes the uses both for synthesis of therapeutic molecules, modification of large biomolecules or antibodies, and in particular, the exciting use in the field of ‘pre-targeting’, for both possible treatment and imaging technologies. We will compare the validity of each reaction when compared to others, and their usefulness in biological systems, as each methodology has clear advantages over the others in differing environments.
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Reporter
Professor Alan C Spivey
Department of Chemistry
Contact details
Tel: +44 (0)20 7594 5841
Email: a.c.spivey@imperial.ac.uk
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