Dec 2013 - Two Articles in J. Lab. Comp. Radiopharm. Published

Helen's and Federica's papers on 68Ga-DOTA labelling for PET pre-targeting & on an 18F glycosylated cyanoquinoline for EGFR imaging are published.

H.L Evans, L. Carroll, E.O Aboagye, A.C Spivey, 'Bioorthogonal chemistry for ⁶⁸Ga radiolabelling of DOTA-containing compounds', J. Lab. Cpd. Radiopharm. 2013, 56,  DOI: 10.1002/jlcr.3153

Abstract: Bioorthogonal reactions, which do not perturb or interfere with biological systems and are characterised by fast reaction kinetics, may be useful tools for radiolabelling biomolecules via a two-step labelling procedure. Here, we demonstrate a series of bioorthogonal radiochemistry reactions using ⁶⁸Ga-DOTA labelled prosthetic groups, highlighting the versatility of this approach for potential imaging applications.

F. Pisaneschi, R.L. Slade, L. Iddon, G.P.C. George, Q.-D. Nguyen, A.C. Spivey, E.O. Aboagye, 'Synthesis of a new fluorine-18 glycosylated ‘click’ cyanoquinoline for the imaging of EGFR', J. Lab. Cpd. Radiopharm. 2013, 56, DOI: 10.1002/jlcr.3170

Abstract: This study reports the synthesis and a preliminary biological evaluation of the new fluorine-18 glycosylated ‘click’ cyanoquinoline [¹⁸F]5, a selective radiotracer for the positron emission tomography imaging of epidermal growth factor receptor.