Dec 2013 - Two Articles in J. Lab. Comp. Radiopharm. Published
Helen's and Federica's papers on 68Ga-DOTA labelling for PET pre-targeting & on an 18F glycosylated cyanoquinoline for EGFR imaging are published.
H.L Evans, L. Carroll, E.O Aboagye, A.C Spivey, 'Bioorthogonal chemistry for 68Ga radiolabelling of DOTA-containing compounds', J. Lab. Cpd. Radiopharm. 2013, 56, DOI: 10.1002/jlcr.3153
Abstract: Bioorthogonal reactions, which do not perturb or interfere with biological systems and are characterised by fast reaction kinetics, may be useful tools for radiolabelling biomolecules via a two-step labelling procedure. Here, we demonstrate a series of bioorthogonal radiochemistry reactions using 68Ga-DOTA labelled prosthetic groups, highlighting the versatility of this approach for potential imaging applications.
F. Pisaneschi, R.L. Slade, L. Iddon, G.P.C. George, Q.-D. Nguyen, A.C. Spivey, E.O. Aboagye, 'Synthesis of a new fluorine-18 glycosylated ‘click’ cyanoquinoline for the imaging of EGFR', J. Lab. Cpd. Radiopharm. 2013, 56, DOI: 10.1002/jlcr.3170
Abstract: This study reports the synthesis and a preliminary biological evaluation of the new fluorine-18 glycosylated ‘click’ cyanoquinoline [18F]5, a selective radiotracer for the positron emission tomography imaging of epidermal growth factor receptor.
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