Imperial News

Jan 2015 - Article in Synlett Published

by Professor Alan C Spivey

James' paper on the Organocatalytic Phosphorylation of Alcohols Using Pyridine-N-oxide is published.

James I. Murray, Rudiger Woscholski and Alan C. Spivey* Organocatalytic Phosphorylation of Alcohols Using Pyridine-N-oxide, Synlett, 2015, ASAP. DOI: 10.1055/s-0034-1379993


Phosphorylation of alcohols by phosphoryl chlorides catalysed by pyridine-N-oxide is reported. The utility of this method is demonstrated through phosphorylation of primary, secondary and a tertiary alcohol as well as phenols under mild reaction conditions and with low catalyst loading (5 mol%).